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Stat6 signal transducer and activator of transcription 6 [ Mus musculus (house mouse) ]

Gene ID: 20852, updated on 15-Jul-2014
Official Symbol
Stat6provided by MGI
Official Full Name
signal transducer and activator of transcription 6provided by MGI
Primary source
MGI:103034
See related
Ensembl:ENSMUSG00000002147; Vega:OTTMUSG00000031818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
See Stat6 in Epigenomics, MapViewer
Location:
10 D3; 10 74.59 cM
Exon count :
23
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 10 NC_000076.6 (127641910..127660987)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene neurexophilin 4 Neighboring gene low density lipoprotein receptor-related protein 1 Neighboring gene uncharacterized LOC102633074 Neighboring gene RIKEN cDNA 1700012D01 gene Neighboring gene uncharacterized LOC102632898 Neighboring gene Ngfi-A binding protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T-helper 1 cell lineage commitment IGI
Inferred from Genetic Interaction
more info
 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to reactive nitrogen species ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
interleukin-4-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-4-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 
mammary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of type 2 immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of isotype switching to IgE isotypes IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to cytokine ISO
Inferred from Sequence Orthology
more info
 
signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
signal transducer and transcription activator 6
Names
signal transducer and transcription activator 6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009284.2NP_033310.2  signal transducer and transcription activator 6

    See proteins identical to NP_033310.2

    Status: VALIDATED

    Source sequence(s)
    AK149563, AK163053, BM122652
    Consensus CDS
    CCDS36082.1
    UniProtKB/Swiss-Prot
    P52633
    Related
    ENSMUSP00000089708, OTTMUSP00000042008, ENSMUST00000092074, OTTMUST00000078897
    Conserved Domains (5) summary
    pfam02864
    Location:273527
    Blast Score: 901
    STAT_bind; STAT protein, DNA binding domain
    cd10377
    Location:517646
    Blast Score: 674
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    pfam01017
    Location:124271
    Blast Score: 360
    STAT_alpha; STAT protein, all-alpha domain
    pfam02865
    Location:2116
    Blast Score: 290
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:655837
    Blast Score: 859
    STAT6_C; STAT6 C-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000076.6 

    Range
    127641910..127660987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513437.1XP_006513500.1  

    Conserved Domains (5) summary
    pfam02864
    Location:330584
    Blast Score: 904
    STAT_bind; STAT protein, DNA binding domain
    cd10377
    Location:574703
    Blast Score: 674
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    pfam01017
    Location:181328
    Blast Score: 363
    STAT_alpha; STAT protein, all-alpha domain
    pfam02865
    Location:59173
    Blast Score: 292
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:712894
    Blast Score: 860
    STAT6_C; STAT6 C-terminal

Alternate Mm_Celera

Genomic

  1. AC_000032.1 

    Range
    130035284..130053348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

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