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Kdr kinase insert domain receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25589, updated on 6-May-2015
Official Symbol
Kdrprovided by RGD
Official Full Name
kinase insert domain receptorprovided by RGD
Primary source
RGD:2965
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Vegfr-2
Summary
receptor for vascular endothelial growth factor (VEGF) [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Orthologs
See Kdr in MapViewer
Location:
chromosome: 14
Exon count:
30
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (34727677..34787127)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (34557361..34618112)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 165 Neighboring gene steroid 5 alpha-reductase 3 Neighboring gene uncharacterized LOC102553643 Neighboring gene v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC93590

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
growth factor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor binding IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor binding ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
branching morphogenesis of an epithelial tube IEA
Inferred from Electronic Annotation
more info
 
branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
calcium-mediated signaling using intracellular calcium source IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
 
calcium-mediated signaling using intracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cell maturation ISO
Inferred from Sequence Orthology
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
embryonic hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
endocardium development ISO
Inferred from Sequence Orthology
more info
 
endochondral bone growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
endothelium development ISO
Inferred from Sequence Orthology
more info
 
endothelium development ISS
Inferred from Sequence or Structural Similarity
more info
 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
hyaluronan metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
 
lymph vessel development IEA
Inferred from Electronic Annotation
more info
 
lymph vessel development ISO
Inferred from Sequence Orthology
more info
 
male gonad development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neurogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vasodilation IGI
Inferred from Genetic Interaction
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxygen levels IEP
Inferred from Expression Pattern
more info
PubMed 
surfactant homeostasis IEA
Inferred from Electronic Annotation
more info
 
surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sorting endosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
vascular endothelial growth factor receptor 2
Names
vascular endothelial growth factor receptor 2
FLK-1
FLK1 kinase insert domain receptor (VEGF receptor 2)
FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
fetal liver kinase 1
kinase insert domain protein receptor
protein-tyrosine kinase receptor flk-1
NP_037194.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013062.1NP_037194.1  vascular endothelial growth factor receptor 2 precursor

    See identical proteins and their annotated locations for NP_037194.1

    Status: PROVISIONAL

    Source sequence(s)
    U93306
    UniProtKB/Swiss-Prot
    O08775
    Conserved Domains (7) summary
    cd00096
    Location:680746
    Ig; Immunoglobulin domain
    smart00408
    Location:676740
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:231324
    IG_like; Immunoglobulin like
    pfam07714
    Location:8301156
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:546648
    Ig_2; Immunoglobulin domain
    cd05103
    Location:8221163
    PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2
    cl11960
    Location:239325
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    34727677..34787127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    31512534..31554989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)