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CYR61 cysteine-rich, angiogenic inducer, 61 [ Homo sapiens (human) ]

Gene ID: 3491, updated on 8-Feb-2015
Official Symbol
CYR61provided by HGNC
Official Full Name
cysteine-rich, angiogenic inducer, 61provided by HGNC
Primary source
HGNC:HGNC:2654
See related
Ensembl:ENSG00000142871; HPRD:09089; MIM:602369; Vega:OTTHUMG00000010577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCN1; GIG1; IGFBP10
Summary
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
Orthologs
See CYR61 in MapViewer
Location:
1p22.3
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (85580761..85583967)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (86046444..86049650)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC646626 Neighboring gene B-cell CLL/lymphoma 10 Neighboring gene dimethylarginine dimethylaminohydrolase 1 Neighboring gene uncharacterized LOC101930232 Neighboring gene zinc finger, HIT-type containing 6 Neighboring gene collagen, type XXIV, alpha 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
apoptotic process involved in heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
atrial septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
atrioventricular valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
chondroblast differentiation IEA
Inferred from Electronic Annotation
more info
 
chorio-allantoic fusion IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
intussusceptive angiogenesis IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cartilage development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phospholipase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of cells IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
proteinaceous extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
protein CYR61
Names
protein CYR61
CCN family member 1
IBP-10
IGF-binding protein 10
IGFBP-10
cysteine-rich heparin-binding protein 61
cysteine-rich, anigogenic inducer, 61
insulin-like growth factor-binding protein 10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001554.4NP_001545.2  protein CYR61 precursor

    See proteins identical to NP_001545.2

    Status: REVIEWED

    Source sequence(s)
    BC009199, BP387218, DA764894
    Consensus CDS
    CCDS706.1
    UniProtKB/Swiss-Prot
    O00622
    UniProtKB/TrEMBL
    Q6FI18
    Related
    ENSP00000398736, OTTHUMP00000012303, ENST00000451137, OTTHUMT00000029187
    Conserved Domains (4) summary
    smart00214
    Location:100159
    VWC; von Willebrand factor (vWF) type C domain
    cl00070
    Location:293375
    GHB_like; Glycoprotein hormone beta chain homologues
    pfam00090
    Location:232272
    TSP_1; Thrombospondin type 1 domain
    pfam00219
    Location:3278
    IGFBP; Insulin-like growth factor binding protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38 Primary Assembly

    Range
    85580761..85583967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    86161864..86165070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 Alternate HuRef

    Range
    84157232..84160438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)