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    APOE apolipoprotein E [ Homo sapiens (human) ]

    Gene ID: 348, updated on 30-Aug-2015
    Official Symbol
    APOEprovided by HGNC
    Official Full Name
    apolipoprotein Eprovided by HGNC
    Primary source
    HGNC:HGNC:613
    See related
    Ensembl:ENSG00000130203; HPRD:00135; MIM:107741; Vega:OTTHUMG00000128901
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AD2; LPG; APO-E; LDLCQ5
    Summary
    The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
    Orthologs
    See APOE in Epigenomics, MapViewer
    Location:
    19q13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (44905749..44909395)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45409039..45412650)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene poliovirus receptor-related 2 (herpesvirus entry mediator B) Neighboring gene translocase of outer mitochondrial membrane 40 homolog (yeast) Neighboring gene apolipoprotein C-I Neighboring gene apolipoprotein C-I pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
    NHGRI GWA Catalog
    A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
    NHGRI GWA Catalog
    A genome-wide scan for common variants affecting the rate of age-related cognitive decline.
    NHGRI GWA Catalog
    A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
    NHGRI GWA Catalog
    ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
    NHGRI GWA Catalog
    An atlas of genetic influences on human blood metabolites.
    NHGRI GWA Catalog
    APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
    NHGRI GWA Catalog
    Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
    NHGRI GWA Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    NHGRI GWA Catalog
    Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
    NHGRI GWA Catalog
    Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.
    NHGRI GWA Catalog
    Common variants at 30 loci contribute to polygenic dyslipidemia.
    NHGRI GWA Catalog
    Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
    NHGRI GWA Catalog
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog
    Examination of the current top candidate genes for AD in a genome-wide association study.
    NHGRI GWA Catalog
    Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.
    NHGRI GWA Catalog
    Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
    NHGRI GWA Catalog
    Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
    NHGRI GWA Catalog
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    NHGRI GWA Catalog
    Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study.
    NHGRI GWA Catalog
    Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
    NHGRI GWA Catalog
    Genome-wide analysis of genetic loci associated with Alzheimer disease.
    NHGRI GWA Catalog
    Genome-wide association analysis of age-at-onset in Alzheimer's disease.
    NHGRI GWA Catalog
    Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
    NHGRI GWA Catalog
    Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
    NHGRI GWA Catalog
    Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
    NHGRI GWA Catalog
    Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
    NHGRI GWA Catalog
    Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
    NHGRI GWA Catalog
    Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
    NHGRI GWA Catalog
    Genome-wide association study of Alzheimer's disease with psychotic symptoms.
    NHGRI GWA Catalog
    Genome-wide association study of Alzheimer's disease.
    NHGRI GWA Catalog
    Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
    NHGRI GWA Catalog
    Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
    NHGRI GWA Catalog
    Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
    NHGRI GWA Catalog
    Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
    NHGRI GWA Catalog
    GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
    NHGRI GWA Catalog
    High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE.
    NHGRI GWA Catalog
    Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
    NHGRI GWA Catalog
    Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
    NHGRI GWA Catalog
    Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
    NHGRI GWA Catalog
    Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
    NHGRI GWA Catalog
    Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
    NHGRI GWA Catalog
    Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
    NHGRI GWA Catalog
    Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
    NHGRI GWA Catalog
    Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog
    Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
    NHGRI GWA Catalog
    Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
    NHGRI GWA Catalog
    Seven new loci associated with age-related macular degeneration.
    NHGRI GWA Catalog
    Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
    NHGRI GWA Catalog
    Sorl1 as an Alzheimer's disease predisposition gene?
    NHGRI GWA Catalog
    SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
    NHGRI GWA Catalog
    SUCLG2 identified as both a determinator of CSF Aß1-42-levels and an attenuator of cognitive decline in Alzheimer's disease.
    NHGRI GWA Catalog
    The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 causes increased neurotoxicity in human neuronal cultures with the ApoE4 allele PubMed
    Tat tat Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein PubMed
    tat The antioxidant properties of human lipidated apoE3 protects neurons from Tat-induced toxicity PubMed
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates expression of six genes, APOE, CCL5, DGKK, GPX5, NOS2, and PXDNL PubMed

    Go to the HIV-1, Human Interaction Database

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
      Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
    • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
      Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
    • Chylomicron-mediated lipid transport, organism-specific biosystem (from REACTOME)
      Chylomicron-mediated lipid transport, organism-specific biosystemChylomicrons transport triacylglycerol, phospholipid, and cholesterol derived from dietary lipid from the small intestine to other tissues of the body. Each chylomicron assembles around a single mole...
    • HDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
      HDL-mediated lipid transport, organism-specific biosystemHDL particles play a central role in the reverse transport of cholesterol, the process by which cholesterol in tissues other than the liver is returned to the liver for conversion to bile salts and e...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
      Lipoprotein metabolism, organism-specific biosystemBecause of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Retinoid metabolism and transport, organism-specific biosystem (from REACTOME)
      Retinoid metabolism and transport, organism-specific biosystemVitamin A (all-trans-retinol) must be taken up, either as carotenes from plants, or as retinyl esters from animal food. The most prominent carotenes are alpha-carotene, lycopene, lutein, beta-cryptox...
    • Scavenging by Class A Receptors, organism-specific biosystem (from REACTOME)
      Scavenging by Class A Receptors, organism-specific biosystemClass A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Statin Pathway, organism-specific biosystem (from WikiPathways)
      Statin Pathway, organism-specific biosystemStatins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • Visual phototransduction, organism-specific biosystem (from REACTOME)
      Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...
    • Vitamin B12 Metabolism, organism-specific biosystem (from WikiPathways)
      Vitamin B12 Metabolism, organism-specific biosystem
      Vitamin B12 Metabolism
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC1571

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    antioxidant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-amyloid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cholesterol transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipoprotein particle binding IEA
    Inferred from Electronic Annotation
    more info
     
    low-density lipoprotein particle receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal chelating activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylcholine-sterol O-acyltransferase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tau protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    very-low-density lipoprotein particle receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    very-low-density lipoprotein particle receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    AMPA glutamate receptor clustering IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NMDA glutamate receptor clustering IDA
    Inferred from Direct Assay
    more info
    PubMed 
    artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cholesterol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chylomicron remnant clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty acid homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    high-density lipoprotein particle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    high-density lipoprotein particle clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    high-density lipoprotein particle remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intracellular transport TAS
    Traceable Author Statement
    more info
    PubMed 
    lipoprotein biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipoprotein metabolic process TAS
    Traceable Author Statement
    more info
     
    long-chain fatty acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    maintenance of location in cell IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of beta-amyloid formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of blood coagulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cholesterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of dendritic spine development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of dendritic spine maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of lipid transport across blood brain barrier IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of phospholipid efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of platelet activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of postsynaptic membrane organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of presynaptic membrane organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nitric oxide mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phototransduction, visible light TAS
    Traceable Author Statement
    more info
     
    positive regulation by host of viral process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of beta-amyloid formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cGMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cholesterol efflux IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cholesterol esterification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dendritic spine development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dendritic spine maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of lipid transport across blood brain barrier IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of low-density lipoprotein particle receptor catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neurofibrillary tangle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phospholipid efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of postsynaptic membrane organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of presynaptic membrane organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    regulation of Cdc42 protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of axon extension TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of beta-amyloid clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of neuronal synaptic plasticity TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of tau-protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to dietary excess IEA
    Inferred from Electronic Annotation
    more info
     
    response to reactive oxygen species NAS
    Non-traceable Author Statement
    more info
    PubMed 
    retinoid metabolic process TAS
    Traceable Author Statement
    more info
     
    reverse cholesterol transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    synaptic transmission, cholinergic TAS
    Traceable Author Statement
    more info
    PubMed 
    triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    triglyceride metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    very-low-density lipoprotein particle clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    very-low-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    very-low-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    very-low-density lipoprotein particle remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    virion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood microparticle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chylomicron IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    dendrite NAS
    Non-traceable Author Statement
    more info
    PubMed 
    early endosome TAS
    Traceable Author Statement
    more info
     
    endocytic vesicle lumen TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    high-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    very-low-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    apolipoprotein E
    Names
    apolipoprotein E3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007084.2 RefSeqGene

      Range
      4968..8614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000041.3NP_000032.1  apolipoprotein E isoform b precursor

      See identical proteins and their annotated locations for NP_000032.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
      Source sequence(s)
      AL037046, BC003557, HY056112
      Consensus CDS
      CCDS12647.1
      UniProtKB/Swiss-Prot
      P02649
      Related
      ENSP00000252486, OTTHUMP00000159143, ENST00000252486, OTTHUMT00000250865
      Conserved Domains (1) summary
      pfam01442
      Location:104299
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    2. NM_001302688.1NP_001289617.1  apolipoprotein E isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL037046, BC003557, BM042032, HY056112
      UniProtKB/Swiss-Prot
      P02649
      Conserved Domains (1) summary
      pfam01442
      Location:130325
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    3. NM_001302689.1NP_001289618.1  apolipoprotein E isoform b precursor

      See identical proteins and their annotated locations for NP_001289618.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
      Source sequence(s)
      AL037046, BC003557, DB486513, HY074384
      Consensus CDS
      CCDS12647.1
      UniProtKB/Swiss-Prot
      P02649
      Conserved Domains (1) summary
      pfam01442
      Location:104299
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    4. NM_001302690.1NP_001289619.1  apolipoprotein E isoform b precursor

      See identical proteins and their annotated locations for NP_001289619.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
      Source sequence(s)
      AL037046, BC003557, CA771535, HY074888
      Consensus CDS
      CCDS12647.1
      UniProtKB/Swiss-Prot
      P02649
      Conserved Domains (1) summary
      pfam01442
      Location:104299
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    5. NM_001302691.1NP_001289620.1  apolipoprotein E isoform b precursor

      See identical proteins and their annotated locations for NP_001289620.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' terminal exon and uses an alternate splice site in another 5' exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
      Source sequence(s)
      AL037046, BC003557, BI550631, HY056112
      Consensus CDS
      CCDS12647.1
      UniProtKB/Swiss-Prot
      P02649
      Conserved Domains (1) summary
      pfam01442
      Location:104299
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

      Range
      44905749..44909395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      45411760..45415406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)