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TNK2 tyrosine kinase, non-receptor, 2 [ Bos taurus (cattle) ]

Gene ID: 280710, updated on 19-Jul-2014
Gene symbol
TNK2
Gene description
tyrosine kinase, non-receptor, 2
Locus tag
BOS_822
See related
Ensembl:ENSBTAG00000021364
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ACK; ACK1
See TNK2 in MapViewer
Location:
chromosome: 1
Exon count :
15
Annotation release Status Assembly Chr Location
103 current Bos_taurus_UMD_3.1 (GCF_000003055.4) 1 AC_000158.1 (71207394..71230157, complement)

Chromosome 1 - AC_000158.1Genomic Context describing neighboring genes Neighboring gene mucin 20, cell surface associated Neighboring gene mucin 4, cell surface associated Neighboring gene uncharacterized LOC101906292 Neighboring gene transferrin receptor (p90, CD71)

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
adherens junction IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
activated CDC42 kinase 1
Names
activated CDC42 kinase 1
ACK-1
activated CDC42 kinase 2
activated p21cdc42Hs kinase
tyrosine kinase non-receptor protein 2
NP_776310.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173885.3NP_776310.2  activated CDC42 kinase 1

    See proteins identical to NP_776310.2

    Status: PROVISIONAL

    Source sequence(s)
    BC118081
    UniProtKB/Swiss-Prot
    Q17R13
    Related
    ENSBTAP00000043771, ENSBTAT00000046471
    Conserved Domains (7) summary
    pfam09027
    Location:447514
    Blast Score: 293
    GTPase_binding; GTPase binding
    cd05040
    Location:130387
    Blast Score: 1342
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam11555
    Location:773840
    Blast Score: 223
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:667
    Blast Score: 316
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126385
    Blast Score: 969
    STYKc; Protein kinase; unclassified specificity
    cd00194
    Location:960994
    Blast Score: 83
    UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
    pfam14604
    Location:395444
    Blast Score: 134
    SH3_9; Variant SH3 domain

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1 Primary Assembly

Genomic

  1. AC_000158.1 

    Range
    71207394..71230157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Btau_4.6.1

Genomic

  1. NC_007299.5 

    Range
    71602573..71625337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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