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KRT16 keratin 16, type I [ Homo sapiens (human) ]

Gene ID: 3868, updated on 4-May-2015
Official Symbol
KRT16provided by HGNC
Official Full Name
keratin 16, type Iprovided by HGNC
Primary source
HGNC:HGNC:6423
See related
Ensembl:ENSG00000186832; HPRD:01018; MIM:148067; Vega:OTTHUMG00000133495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A
Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
Orthologs
See KRT16 in MapViewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (41609778..41612827, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39766030..39769079, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 9, type I Neighboring gene keratin 14, type I Neighboring gene keratin 17, type I Neighboring gene keratin 42 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
aging IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
establishment of skin barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
hair cycle IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
keratinization ISS
Inferred from Sequence or Structural Similarity
more info
 
keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
keratinocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 
morphogenesis of an epithelium ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
keratin, type I cytoskeletal 16
Names
keratin, type I cytoskeletal 16
CK-16
cytokeratin 16
cytokeratin-16
focal non-epidermolytic palmoplantar keratoderma
keratin-16

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008301.1 RefSeqGene

    Range
    5001..8050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005557.3NP_005548.2  keratin, type I cytoskeletal 16

    See identical proteins and their annotated locations for NP_005548.2

    Status: REVIEWED

    Source sequence(s)
    AK290853, BC039169, DC394235
    Consensus CDS
    CCDS11401.1
    UniProtKB/Swiss-Prot
    P08779
    Related
    ENSP00000301653, OTTHUMP00000164740, ENST00000301653, OTTHUMT00000257408
    Conserved Domains (2) summary
    pfam00038
    Location:116427
    Filament; Intermediate filament protein
    cl14876
    Location:239327
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    41609778..41612827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    40001344..40004393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)