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    EIF5A2 eukaryotic translation initiation factor 5A2 [ Homo sapiens (human) ]

    Gene ID: 56648, updated on 5-Jul-2015
    Official Symbol
    EIF5A2provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 5A2provided by HGNC
    Primary source
    HGNC:HGNC:3301
    See related
    Ensembl:ENSG00000163577; HPRD:10426; MIM:605782; Vega:OTTHUMG00000158958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF-5A2; eIF5AII
    Orthologs
    See EIF5A2 in Epigenomics, MapViewer
    Location:
    3q26.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (170888415..170908637, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (170606204..170626426, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, Ro-associated Y5 pseudogene 3 Neighboring gene ribosomal protein L22-like 1 Neighboring gene kruppel-like factor 7 pseudogene 1 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-lysine modification to peptidyl-hypusine TAS
    Traceable Author Statement
    more info
     
    polyamine homeostasis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    eukaryotic translation initiation factor 5A-2
    Names
    eIF-5A-2
    eukaryotic initiation factor 5A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020390.5NP_065123.1  eukaryotic translation initiation factor 5A-2

      See identical proteins and their annotated locations for NP_065123.1

      Status: VALIDATED

      Source sequence(s)
      AY205261
      Consensus CDS
      CCDS3214.1
      UniProtKB/Swiss-Prot
      Q9GZV4
      Related
      ENSP00000295822, OTTHUMP00000213742, ENST00000295822, OTTHUMT00000352681
      Conserved Domains (2) summary
      PLN03107
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      cd04468
      Location:84152
      S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

      Range
      170888415..170908637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      170569381..170589612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)