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    Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal [ Mus musculus (house mouse) ]

    Gene ID: 20597, updated on 1-Sep-2016
    Official Symbol
    Smpd1provided by MGI
    Official Full Name
    sphingomyelin phosphodiesterase 1, acid lysosomalprovided by MGI
    Primary source
    MGI:MGI:98325
    See related
    Ensembl:ENSMUSG00000037049 Vega:OTTMUSG00000060466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ASM; aSMase; A-SMase; Zn-SMase
    Orthologs
    Location:
    7 E3; 7 55.9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (105554360..105558389)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (112702874..112706903)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36847 Neighboring gene predicted gene, 39063 Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 1 Neighboring gene hemopexin

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acid sphingomyelin phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acid sphingomyelin phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    sphingomyelin phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    sphingomyelin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    termination of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    lamellar body ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    sphingomyelin phosphodiesterase
    Names
    acid sphingomyelinase
    NP_035551.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011421.2NP_035551.1  sphingomyelin phosphodiesterase precursor

      See identical proteins and their annotated locations for NP_035551.1

      Status: VALIDATED

      Source sequence(s)
      AK145702, BP760033
      Consensus CDS
      CCDS21653.1
      UniProtKB/Swiss-Prot
      Q04519
      Related
      ENSMUSP00000042187, OTTMUSP00000076958, ENSMUST00000046983, OTTMUST00000147939
      Conserved Domains (3) summary
      smart00741
      Location:85158
      SapB; Saposin (B) Domains
      cd00842
      Location:199494
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
      pfam00149
      Location:252459
      Metallophos; Calcineurin-like phosphoesterase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      105554360..105558389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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