Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    NME1 NME/NM23 nucleoside diphosphate kinase 1 [ Homo sapiens (human) ]

    Gene ID: 4830, updated on 7-Jan-2016
    Official Symbol
    NME1provided by HGNC
    Official Full Name
    NME/NM23 nucleoside diphosphate kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:7849
    See related
    Ensembl:ENSG00000239672; HPRD:01131; MIM:156490; Vega:OTTHUMG00000137474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NB; AWD; NBS; GAAD; NDKA; NM23; NDPKA; NDPK-A; NM23-H1
    Summary
    This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
    Orthologs
    See NME1 in Epigenomics, MapViewer
    Location:
    17q21.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (51153559..51162089)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49230920..49239450)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371826 Neighboring gene sperm associated antigen 9 Neighboring gene uncharacterized LOC105371827 Neighboring gene NME1-NME2 readthrough Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene mbt domain containing 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    SiRNA-mediated knockdown of one of the components of the SET complex, NM23-H1, inhibits HIV-1 infection with significantly reduced levels of integrated HIV-1 DNA and viral production in HeLa-CD4 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    reverse transcriptase gag-pol HIV-1 RT forms a complex with NDPKA in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    deoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    intermediate filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoside diphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ribosomal small subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    lactation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myeloid leukocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    nucleobase-containing small molecule interconversion TAS
    Traceable Author Statement
    more info
     
    nucleobase-containing small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    nucleoside diphosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside triphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    purine nucleotide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    pyrimidine nucleotide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    response to amine IEA
    Inferred from Electronic Annotation
    more info
     
    response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    nucleoside diphosphate kinase A
    Names
    NDP kinase A
    granzyme A-activated DNase
    metastasis inhibition factor nm23
    non-metastatic cells 1, protein (NM23A) expressed in
    tumor metastatic process-associated protein
    NP_000260.1
    NP_937818.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021169.1 RefSeqGene

      Range
      5001..13531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000269.2NP_000260.1  nucleoside diphosphate kinase A isoform b

      See identical proteins and their annotated locations for NP_000260.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AF487339, BE727815, BF965472, BG715560, BI666785, BM479520, BU600979
      Consensus CDS
      CCDS11579.1
      UniProtKB/Swiss-Prot
      P15531
      Related
      ENSP00000376892, OTTHUMP00000174723, ENST00000393196, OTTHUMT00000268662
      Conserved Domains (2) summary
      cd04413
      Location:5134
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
      pfam00334
      Location:5139
      NDK; Nucleoside diphosphate kinase
    2. NM_198175.1NP_937818.1  nucleoside diphosphate kinase A isoform a

      See identical proteins and their annotated locations for NP_937818.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AF487339, AL360191, BE727815, BF965472, BG531372, BG715560, BG757842, BI666785, BM479520
      Consensus CDS
      CCDS11578.1
      UniProtKB/Swiss-Prot
      P15531
      Related
      ENSP00000337060, OTTHUMP00000174724, ENST00000336097, OTTHUMT00000268663
      Conserved Domains (2) summary
      cd04413
      Location:30159
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
      pfam00334
      Location:30164
      NDK; Nucleoside diphosphate kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      51153559..51162089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      49295556..49304086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)