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SUCO SUN domain containing ossification factor [ Homo sapiens (human) ]

Gene ID: 51430, updated on 7-Aug-2014
Official Symbol
SUCOprovided by HGNC
Official Full Name
SUN domain containing ossification factorprovided by HGNC
Primary source
HGNC:1240
See related
Ensembl:ENSG00000094975; HPRD:12732; Vega:OTTHUMG00000034839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CH1; OPT; SLP1; C1orf9
See SUCO in Epigenomics, MapViewer
Location:
1q24
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (172532349..172611833)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (172501494..172580973)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dynamin 3 Neighboring gene uncharacterized LOC102724528 Neighboring gene chromosome 1 open reading frame 105 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C Neighboring gene Fas ligand (TNF superfamily, member 6) Neighboring gene solute carrier family 25, member 38 pseudogene 1

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of collagen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
SUN domain-containing ossification factor
Names
SUN domain-containing ossification factor
osteopotentia
SUN-like protein 1
membrane protein CH1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282750.1NP_001269679.1  SUN domain-containing ossification factor isoform 3 precursor

    See proteins identical to NP_001269679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream AUG, compared to variant 2. The encoded protein (isoform 3) is shorter than isoform 2.
    Source sequence(s)
    AJ250075, AK302509, AL035291, DB093941
    Consensus CDS
    CCDS65727.1
    UniProtKB/TrEMBL
    B4DYM4
    UniProtKB/Swiss-Prot
    Q9UBS9
    Conserved Domains (1) summary
    pfam07738
    Location:286415
    Blast Score: 426
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. NM_001282751.1NP_001269680.1  SUN domain-containing ossification factor isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the 5' UTR and coding region, compared to variant 2. This variant represents translation initiation at a downstream AUG compared to variant 2; the 5'-most initiation codon, as used in variant 2, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG.
    Source sequence(s)
    AJ250075, AL035291, BC144487, DB093941
    Consensus CDS
    CCDS72984.1
    UniProtKB/Swiss-Prot
    Q9UBS9
    Conserved Domains (1) summary
    pfam04899
    Location:373442
    Blast Score: 81
    MbeD_MobD; MbeD/MobD like
  3. NM_014283.4NP_055098.1  SUN domain-containing ossification factor isoform 1 precursor

    See proteins identical to NP_055098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region and initiates translation at a downstream AUG, compared to variant 2. The encoded protein (isoform 1) is shorter than isoform 2.
    Source sequence(s)
    AJ250075, AL035291, BC137125, DB093941
    Consensus CDS
    CCDS1303.1
    UniProtKB/Swiss-Prot
    Q9UBS9
    Related
    ENSP00000263688, OTTHUMP00000032706, ENST00000263688, OTTHUMT00000084273
    Conserved Domains (2) summary
    pfam04899
    Location:9361005
    Blast Score: 86
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:323452
    Blast Score: 426
    Sad1_UNC; Sad1 / UNC-like C-terminal
  4. NM_016227.3NP_057311.3  SUN domain-containing ossification factor isoform 2

    See proteins identical to NP_057311.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AF097535, AJ250075, AL035291, Z94054
    Consensus CDS
    CCDS65726.1
    UniProtKB/Swiss-Prot
    Q9UBS9
    Conserved Domains (2) summary
    pfam04899
    Location:10871156
    Blast Score: 84
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:481603
    Blast Score: 428
    Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    172532349..172611833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711374.1XP_006711437.1  

    Conserved Domains (2) summary
    pfam04899
    Location:929998
    Blast Score: 86
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:323445
    Blast Score: 427
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. XM_006711375.1XP_006711438.1  

    Conserved Domains (2) summary
    pfam04899
    Location:899968
    Blast Score: 86
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:286415
    Blast Score: 426
    Sad1_UNC; Sad1 / UNC-like C-terminal
  3. XM_006711376.1XP_006711439.1  

    Conserved Domains (2) summary
    pfam04899
    Location:892961
    Blast Score: 86
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:286408
    Blast Score: 427
    Sad1_UNC; Sad1 / UNC-like C-terminal
  4. XM_005245251.2XP_005245308.1  

    Conserved Domains (2) summary
    pfam04899
    Location:9361005
    Blast Score: 84
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:323452
    Blast Score: 427
    Sad1_UNC; Sad1 / UNC-like C-terminal

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    143725745..143805573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    173923641..174003286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)