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LTA4H leukotriene A4 hydrolase [ Homo sapiens (human) ]

Gene ID: 4048, updated on 6-Jul-2014
Official Symbol
LTA4Hprovided by HGNC
Official Full Name
leukotriene A4 hydrolaseprovided by HGNC
Primary source
HGNC:6710
See related
Ensembl:ENSG00000111144; HPRD:01056; MIM:151570; Vega:OTTHUMG00000170355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
See LTA4H in Epigenomics, MapViewer
Location:
12q22
Exon count :
20
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (96000753..96043520, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96394531..96437298, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene amidohydrolase domain containing 1 Neighboring gene uncharacterized LOC102723340 Neighboring gene uncharacterized LOC101928830 Neighboring gene histidine ammonia-lyase Neighboring gene transfer RNA-Asp (GTC) 2-6 Neighboring gene yippee-like 5 (Drosophila) pseudogene 3 Neighboring gene ELK3, ETS-domain protein (SRF accessory protein 2)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
NHGRI GWA Catalog
  • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
    Arachidonic acid metabolism, organism-specific biosystem
    Arachidonic acid metabolism
  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Arachidonic acid metabolism, conserved biosystem (from KEGG)
    Arachidonic acid metabolism, conserved biosystem
    Arachidonic acid metabolism
  • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
    Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
    Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
  • leukotriene biosynthesis, organism-specific biosystem (from BIOCYC)
    leukotriene biosynthesis, organism-specific biosystemLeukotrienes are proinflammatory metabolites of arachidonic acid that activate and amplify innate and adaptive immune responses. They also have roles in pathologic immune responses, mediating contrac...
  • leukotriene biosynthesis, conserved biosystem (from BIOCYC)
    leukotriene biosynthesis, conserved biosystemLeukotrienes are proinflammatory metabolites of arachidonic acid that activate and amplify innate and adaptive immune responses. They also have roles in pathologic immune responses, mediating contrac...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
epoxide hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
epoxide hydrolase activity TAS
Traceable Author Statement
more info
PubMed 
leukotriene-A4 hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
leukotriene-A4 hydrolase activity TAS
Traceable Author Statement
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity TAS
Traceable Author Statement
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid metabolic process TAS
Traceable Author Statement
more info
 
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
leukotriene metabolic process TAS
Traceable Author Statement
more info
 
peptide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
leukotriene A-4 hydrolase
Names
leukotriene A-4 hydrolase
LTA-4 hydrolase
NP_000886.1
NP_001243572.1
NP_001243573.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000895.2NP_000886.1  leukotriene A-4 hydrolase isoform 1

    See proteins identical to NP_000886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    DB019628, J03459, R41544
    Consensus CDS
    CCDS9059.1
    UniProtKB/Swiss-Prot
    P09960
    Related
    ENSP00000228740, OTTHUMP00000243570, ENST00000228740, OTTHUMT00000408655
    Conserved Domains (3) summary
    cd09599
    Location:6450
    Blast Score: 2055
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    TIGR02411
    Location:6608
    Blast Score: 2713
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
    pfam09127
    Location:464608
    Blast Score: 516
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
  2. NM_001256643.1NP_001243572.1  leukotriene A-4 hydrolase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BC032528, BX647158, DC358373, R41544
    Consensus CDS
    CCDS58267.1
    UniProtKB/Swiss-Prot
    P09960
    Related
    ENSP00000449958, OTTHUMP00000243571, ENST00000552789, OTTHUMT00000408657
    Conserved Domains (3) summary
    cd09599
    Location:30426
    Blast Score: 1922
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    TIGR02411
    Location:30584
    Blast Score: 2552
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
    pfam09127
    Location:440584
    Blast Score: 514
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
  3. NM_001256644.1NP_001243573.1  leukotriene A-4 hydrolase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK298017, AK308184, R41544
    Consensus CDS
    CCDS58266.1
    UniProtKB/Swiss-Prot
    P09960
    Related
    ENSP00000395051, OTTHUMP00000243572, ENST00000413268, OTTHUMT00000408660
    Conserved Domains (2) summary
    cd09599
    Location:30426
    Blast Score: 1921
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    pfam09127
    Location:440485
    Blast Score: 134
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    96000753..96043520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268871.1XP_005268928.1  

    UniProtKB/Swiss-Prot
    P09960
    Conserved Domains (2) summary
    cd09599
    Location:6450
    Blast Score: 2053
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    pfam09127
    Location:464509
    Blast Score: 135
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    93456404..93499169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    96359522..96402289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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