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Fyn Fyn proto-oncogene [ Mus musculus (house mouse) ]

Gene ID: 14360, updated on 25-Jan-2015
Official Symbol
Fynprovided by MGI
Official Full Name
Fyn proto-oncogeneprovided by MGI
Primary source
MGI:MGI:95602
See related
Ensembl:ENSMUSG00000019843; Vega:OTTMUSG00000034130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI448320; AW552119
Orthologs
See Fyn in MapViewer
Location:
10 B1; 10 20.51 cM
Exon count:
17
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 10 NC_000076.6 (39369769..39565381)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31562 Neighboring gene predicted gene, 31616 Neighboring gene predicted gene 16364 Neighboring gene RIKEN cDNA E130307A14 gene Neighboring gene predicted gene 16365 Neighboring gene TRAF3 interacting protein 2 Neighboring gene predicted gene 8899

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC115870

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
 
CD8 receptor binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
T cell receptor binding ISO
Inferred from Sequence Orthology
more info
 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
glycoprotein binding ISO
Inferred from Sequence Orthology
more info
 
growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to peptide hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to platelet-derived growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of mechanical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
myelination TAS
Traceable Author Statement
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol IGI
Inferred from Genetic Interaction
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tyrosine-protein kinase Fyn
Names
tyrosine-protein kinase Fyn
p59-Fyn
Src Kinase p59
proto-oncogene c-Fyn
proto-oncogene tyrosine-protein kinase Fyn
NP_001116364.1
NP_001116365.1
NP_032080.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122892.1NP_001116364.1  tyrosine-protein kinase Fyn isoform b

    See proteins identical to NP_001116364.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame exon in the coding region and differs in the 5' UTR compared to variant 1. It encodes an isoform (b) with a different and shorter internal segment compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    BC092217, BE952821, BF662030, BQ714273
    Consensus CDS
    CCDS23788.1
    UniProtKB/Swiss-Prot
    P39688
    Conserved Domains (4) summary
    cd10368
    Location:145245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:270517
    Pkinase_Tyr; Protein tyrosine kinase
    cd05070
    Location:258531
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  2. NM_001122893.1NP_001116365.1  tyrosine-protein kinase Fyn isoform a

    See proteins identical to NP_001116365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC092217, BE952821, BF662030, BQ179147, BQ714273, M27266
    Consensus CDS
    CCDS48538.1
    UniProtKB/Swiss-Prot
    P39688
    Related
    ENSMUSP00000097547, OTTMUSP00000046778, ENSMUST00000099967, OTTMUST00000086387
    Conserved Domains (4) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:271520
    Pkinase_Tyr; Protein tyrosine kinase
    cd05070
    Location:261534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  3. NM_008054.2NP_032080.2  tyrosine-protein kinase Fyn isoform b

    See proteins identical to NP_032080.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the coding region compared to variant 1. It encodes an isoform (b) with a different and shorter internal segment compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    BC092217, BE952821, BF662030, BQ714273, M27266
    Consensus CDS
    CCDS23788.1
    UniProtKB/Swiss-Prot
    P39688
    Related
    ENSMUSP00000057707, OTTMUSP00000046777, ENSMUST00000063091, OTTMUST00000086386
    Conserved Domains (4) summary
    cd10368
    Location:145245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:270517
    Pkinase_Tyr; Protein tyrosine kinase
    cd05070
    Location:258531
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000076.6 

    Range
    39369769..39565381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512540.1XP_006512603.1  

    See proteins identical to XP_006512603.1

    UniProtKB/Swiss-Prot
    P39688
    Conserved Domains (4) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:271520
    Pkinase_Tyr; Protein tyrosine kinase
    cd05070
    Location:261534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  2. XM_006512539.1XP_006512602.1  

    See proteins identical to XP_006512602.1

    UniProtKB/Swiss-Prot
    P39688
    Conserved Domains (4) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:271520
    Pkinase_Tyr; Protein tyrosine kinase
    cd05070
    Location:261534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  3. XM_006512537.1XP_006512600.1  

    Conserved Domains (4) summary
    cd10418
    Location:184284
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:124179
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:310559
    Pkinase_Tyr; Protein tyrosine kinase
    cd05070
    Location:300573
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  4. XM_006512538.1XP_006512601.1  

    Conserved Domains (4) summary
    cd10368
    Location:184284
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:124179
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:309556
    Pkinase_Tyr; Protein tyrosine kinase
    cd05070
    Location:297570
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

Alternate Mm_Celera

Genomic

  1. AC_000032.1 

    Range
    40254667..40450960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)