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    FPR2 formyl peptide receptor 2 [ Homo sapiens (human) ]

    Gene ID: 2358, updated on 22-Sep-2016
    Official Symbol
    FPR2provided by HGNC
    Official Full Name
    formyl peptide receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:3827
    See related
    Ensembl:ENSG00000171049 HPRD:00647; MIM:136538; Vega:OTTHUMG00000183501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALXR; HM63; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; LXA4R; FMLP-R-II
    Orthologs
    Location:
    19q13.41
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (51752026..51770526)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52264453..52273779)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hyaluronan synthase 1 Neighboring gene formyl peptide receptor 1 Neighboring gene uncharacterized LOC105372448 Neighboring gene uncharacterized LOC105369197 Neighboring gene formyl peptide receptor 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env FPRL1 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor. The gp120 V3 crown is an important determinant for the efficient FPRL1 usage by the type-C virus PubMed
    env A synthetic peptide domain of the V3 region of HIV-1 gp120 activates the FPRL1 receptor in monocytes and neutrophils and causes reduced response to several chemokines that use multiple cell receptors, including SDF-1alpha and RANTES PubMed
    env A synthetic peptide corresponding to amino acid residues 414-434 of HIV-1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R PubMed
    Envelope transmembrane glycoprotein gp41 env FPRL1 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor PubMed
    env Matriptase, a serine protease, efficiently cleaves the HR1 portion of HIV-1 gp41 into a 22-residue chemotactic peptide MAT-1, leading to chemotaxis by using FPR2 in primary neutrophils PubMed
    env HIV-1 gp41 activates innate host immune cells through FPRL1, and the activation of FPRL1 by gp41 further induces the phosphorylation of the chemokine receptor CCR5 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    N-formyl peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    complement receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    leukocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    movement of cell or subcellular component TAS
    Traceable Author Statement
    more info
    PubMed 
    phospholipase C-activating G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    N-formyl peptide receptor 2
    Names
    FMLP-R-I
    FMLP-related receptor I
    LXA4 receptor
    RFP
    formyl peptide receptor-like 1
    lipoxin A4 receptor (formyl peptide receptor related)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005738.1NP_001005738.1  N-formyl peptide receptor 2

      See identical proteins and their annotated locations for NP_001005738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC071722, BM922150, D10922
      Consensus CDS
      CCDS12840.1
      UniProtKB/Swiss-Prot
      P25090
      UniProtKB/TrEMBL
      A0A024R4P3
      Related
      ENSP00000340191, OTTHUMP00000271853, ENST00000340023, OTTHUMT00000466909
      Conserved Domains (1) summary
      pfam00001
      Location:43302
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_001462.3NP_001453.1  N-formyl peptide receptor 2

      See identical proteins and their annotated locations for NP_001453.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      D10922, X63819
      Consensus CDS
      CCDS12840.1
      UniProtKB/Swiss-Prot
      P25090
      UniProtKB/TrEMBL
      A0A024R4P3
      Related
      ENSP00000468897, OTTHUMP00000271856, ENST00000598776, OTTHUMT00000466912
      Conserved Domains (1) summary
      pfam00001
      Location:43302
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      51752026..51770526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723120.3XP_006723183.1  

      See identical proteins and their annotated locations for XP_006723183.1

      UniProtKB/Swiss-Prot
      P25090
      UniProtKB/TrEMBL
      A0A024R4P3
      Conserved Domains (1) summary
      pfam00001
      Location:43302
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_017026542.1XP_016882031.1  

      Conserved Domains (1) summary
      pfam00001
      Location:43302
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      52266274..52275599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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