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    Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25559, updated on 25-Jul-2015
    Official Symbol
    Abcc8provided by RGD
    Official Full Name
    ATP-binding cassette, subfamily C (CFTR/MRP), member 8provided by RGD
    Primary source
    RGD:3786
    See related
    Ensembl:ENSRNOG00000021130
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sur; Sur1
    Summary
    binds sulfonylurea; subunit of the ATP-sensitive potassium channel K(ATP), which is composed of Sur1 and the inwardly rectifying K(+) channel subunit, Kir6.2 [RGD, Feb 2006]
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    See Abcc8 in MapViewer
    Location:
    1q22
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102110436..102191359, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (103194473..103275508, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene band 4.1-like protein 5-like Neighboring gene potassium channel, inwardly rectifying subfamily J, member 11 Neighboring gene Usher syndrome 1C Neighboring gene otogelin Neighboring gene uncharacterized LOC103691114

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ATPase activity, coupled to transmembrane movement of substances IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel binding IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sulfonylurea receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    sulfonylurea receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to zinc ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    ATP-sensitive potassium channel complex TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ATP-binding cassette sub-family C member 8
    Names
    ATP-binding cassette transporter sub-family C member 8
    ATP-binding cassette, sub-family C (CFTR/MRP), member 8
    sulfonylurea receptor 1
    sulphonylurea receptor 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013039.2NP_037171.2  ATP-binding cassette sub-family C member 8

      See identical proteins and their annotated locations for NP_037171.2

      Status: PROVISIONAL

      Source sequence(s)
      X97279
      UniProtKB/Swiss-Prot
      Q09429
      Related
      ENSRNOP00000028696, ENSRNOT00000028696
      Conserved Domains (4) summary
      cd03288
      Location:13431582
      ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
      pfam00664
      Location:10131295
      ABC_membrane; ABC transporter transmembrane region
      TIGR01271
      Location:2231582
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl21455
      Location:679907
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      102110436..102191359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759319.1XP_008757541.1  

      Conserved Domains (3) summary
      pfam00664
      Location:10231305
      ABC_membrane; ABC transporter transmembrane region
      TIGR01271
      Location:2331592
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl21455
      Location:13531592
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_008759321.1XP_008757543.1  

      See identical proteins and their annotated locations for XP_008757543.1

      UniProtKB/TrEMBL
      Q70X90
      Conserved Domains (3) summary
      pfam00664
      Location:9871269
      ABC_membrane; ABC transporter transmembrane region
      TIGR01271
      Location:1971556
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl21455
      Location:13171556
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_008759320.1XP_008757542.1  

      UniProtKB/Swiss-Prot
      Q09429
      Conserved Domains (4) summary
      cd03288
      Location:13421581
      ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
      pfam00664
      Location:10121294
      ABC_membrane; ABC transporter transmembrane region
      TIGR01271
      Location:2231581
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl21455
      Location:679906
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. XM_008759322.1XP_008757544.1  

      Conserved Domains (4) summary
      cd03288
      Location:13521591
      ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
      pfam00664
      Location:10221304
      ABC_membrane; ABC transporter transmembrane region
      TIGR01271
      Location:2231591
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl21455
      Location:679916
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_590147.1 RNA Sequence

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      90849685..90928224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)