Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Usp4 ubiquitin specific peptidase 4 (proto-oncogene) [ Mus musculus (house mouse) ]

    Gene ID: 22258, updated on 24-Jun-2016
    Official Symbol
    Usp4provided by MGI
    Official Full Name
    ubiquitin specific peptidase 4 (proto-oncogene)provided by MGI
    Primary source
    MGI:MGI:98905
    See related
    Ensembl:ENSMUSG00000032612 Vega:OTTMUSG00000050819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Unp; mKIAA4155; F730026I20Rik
    Orthologs
    Location:
    9 F2; 9 59.25 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (108347818..108392545)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108250162..108294860)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ras homolog family member A Neighboring gene glutathione peroxidase 1 Neighboring gene ribosomal protein S2, pseudogene 11 Neighboring gene RIKEN cDNA 1700102P08 gene Neighboring gene coiled-coil domain containing 36 Neighboring gene cDNA sequence BC048562

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA4155

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    adenosine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 4
    Names
    deubiquitinating enzyme 4
    ubiquitin specific protease 4 (proto-oncogene)
    ubiquitin thioesterase 4
    ubiquitin thiolesterase 4
    ubiquitin-specific-processing protease 4
    ubiquitous nuclear protein
    NP_001298086.1
    NP_035808.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311157.1NP_001298086.1  ubiquitin carboxyl-terminal hydrolase 4 isoform 2

      See identical proteins and their annotated locations for NP_001298086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC161260, AK164245, AK187607, AK199674, BB770947, BE982062, BY322979, CA548182, CK624008
      Consensus CDS
      CCDS81074.1
      UniProtKB/TrEMBL
      A0A0A6YW28, Q3TPN5
      Conserved Domains (5) summary
      smart00695
      Location:27125
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:35875
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:728873
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam14836
      Location:139226
      Ubiquitin_3; Ubiquitin-like domain
      cl02553
      Location:255439
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    2. NM_011678.2NP_035808.2  ubiquitin carboxyl-terminal hydrolase 4 isoform 1

      See identical proteins and their annotated locations for NP_035808.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK149964, BY322979, CD741063
      Consensus CDS
      CCDS23523.1
      UniProtKB/Swiss-Prot
      P35123
      Related
      ENSMUSP00000035237, OTTMUSP00000069251, ENSMUST00000035237, OTTMUST00000128774
      Conserved Domains (5) summary
      smart00695
      Location:27125
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:35922
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:775920
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam14836
      Location:139226
      Ubiquitin_3; Ubiquitin-like domain
      cl02553
      Location:302486
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      108347818..108392545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511699.3XP_006511762.1  

      Conserved Domains (3) summary
      smart00695
      Location:27125
      DUSP; Domain in ubiquitin-specific proteases
      pfam14836
      Location:139226
      Ubiquitin_3; Ubiquitin-like domain
      cl02553
      Location:752852
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    2. XM_006511700.2XP_006511763.1  

      Related
      ENSMUSP00000141321, OTTMUSP00000069252
      Conserved Domains (3) summary
      smart00695
      Location:27125
      DUSP; Domain in ubiquitin-specific proteases
      pfam14836
      Location:139226
      Ubiquitin_3; Ubiquitin-like domain
      cl02553
      Location:775847
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    3. XM_006511696.1XP_006511759.1  

      Conserved Domains (5) summary
      smart00695
      Location:27125
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:35927
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:752925
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam14836
      Location:139226
      Ubiquitin_3; Ubiquitin-like domain
      cl02553
      Location:302486
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    4. XM_006511697.1XP_006511760.1  

      Conserved Domains (5) summary
      smart00695
      Location:27125
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:35880
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:705878
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam14836
      Location:139226
      Ubiquitin_3; Ubiquitin-like domain
      cl02553
      Location:255439
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...