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    CDC42 Rho family GTPase CDC42 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 850930, updated on 7-Feb-2016
    Gene symbol
    CDC42
    Gene description
    Rho family GTPase CDC42
    Primary source
    SGD:S000004219
    Locus tag
    YLR229C
    Gene type
    protein coding
    RNA name
    Rho family GTPase CDC42
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See CDC42 in MapViewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (604212..604787, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Ecm22p Neighboring gene tRNA Neighboring gene kynureninase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    budding cell apical bud growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    budding cell isotropic bud growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pheromone-dependent signal transduction involved in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of exocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of exocytosis IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    positive regulation of pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of exocyst localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of initiation of mating projection growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to pheromone IEA
    Inferred from Electronic Annotation
    more info
     
    septin ring organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular bud neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular bud tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    mating projection tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    septin ring IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    Rho family GTPase CDC42
    NP_013330.1
    • Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      604212..604787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182116.1NP_013330.1  Rho family GTPase CDC42 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_013330.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19073
      Conserved Domains (2) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
      pfam00071
      Location:5173
      Ras; Ras family