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Lepr leptin receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24536, updated on 6-May-2015
Official Symbol
Leprprovided by RGD
Official Full Name
leptin receptorprovided by RGD
Primary source
RGD:3001
See related
Ensembl:ENSRNOG00000023664
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Fa
Summary
receptor for leptin; may have a role in body weight maintainence [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Orthologs
See Lepr in MapViewer
Location:
5q33
Exon count:
19
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (120503475..120682281)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (124380327..124525200) , (124555678..124556585)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene adenylate kinase 4 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 6 Neighboring gene uncharacterized LOC102547589 Neighboring gene leptin receptor overlapping transcript Neighboring gene chromatin assembly factor 1 subunit A-like Neighboring gene PRAME family member 12-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
peptide hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-hormone receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
generation of precursor metabolites and energy NAS
Non-traceable Author Statement
more info
PubMed 
leptin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
ovulation from ovarian follicle IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to leptin IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
leptin receptor
Names
leptin receptor
LEP-R
Leptin receptor (fatty)
OB receptor
OB-R

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012596.1NP_036728.1  leptin receptor precursor

    See identical proteins and their annotated locations for NP_036728.1

    Status: PROVISIONAL

    Source sequence(s)
    U52966
    UniProtKB/Swiss-Prot
    Q62959
    Related
    ENSRNOP00000046647, ENSRNOT00000044131
    Conserved Domains (2) summary
    cd00063
    Location:236328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:334420
    Lep_receptor_Ig; Ig-like C2-type domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    120503475..120682281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    114817255..114982861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)