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    Socs3 suppressor of cytokine signaling 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89829, updated on 27-Aug-2016
    Official Symbol
    Socs3provided by RGD
    Official Full Name
    suppressor of cytokine signaling 3provided by RGD
    Primary source
    RGD:621087
    See related
    Ensembl:ENSRNOG00000002946
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cish3; Ssi-3; Socs-3
    Summary
    regulates cytokine levels to modulate inflammation [RGD, Feb 2006]
    Orthologs
    Location:
    10q32.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106973863..106976969, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (106611459..106616694, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 235 Neighboring gene similar to threonine aldolase 1 Neighboring gene phosphatidylglycerophosphate synthase 1 Neighboring gene dynein, axonemal, heavy chain 17 Neighboring gene uncharacterized LOC103693482

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • ECS complex, organism-specific biosystem (from KEGG)
      ECS complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • ECS complex, conserved biosystem (from KEGG)
      ECS complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-4 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 Signaling Pathway, organism-specific biosystem
      IL-4 Signaling Pathway
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystem
      IL-6 Signaling Pathway
    • IL-9 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-9 Signaling Pathway, organism-specific biosystem
      IL-9 Signaling Pathway
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Insulin resistance, organism-specific biosystem (from KEGG)
      Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Interleukin-6 family signaling, organism-specific biosystem (from REACTOME)
      Interleukin-6 family signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Interleukin-6 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-6 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • JAK-STAT signaling, organism-specific biosystem (from KEGG)
      JAK-STAT signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • JAK-STAT signaling, conserved biosystem (from KEGG)
      JAK-STAT signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • PTK6 Activates STAT3, organism-specific biosystem (from REACTOME)
      PTK6 Activates STAT3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
      Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Prolactin signaling pathway, conserved biosystem (from KEGG)
      Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Regulation of IFNG signaling, organism-specific biosystem (from REACTOME)
      Regulation of IFNG signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by PTK6, organism-specific biosystem (from REACTOME)
      Signaling by PTK6, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
      TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    JAK-STAT cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    JAK-STAT cascade IEA
    Inferred from Electronic Annotation
    more info
     
    JAK-STAT cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    branching involved in labyrinthine layer morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in labyrinthine layer morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of JAK-STAT cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    placenta blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    placenta blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell growth TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to food IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to gamma radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to heat IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    spongiotrophoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    spongiotrophoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    trophoblast giant cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    trophoblast giant cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    suppressor of cytokine signaling 3
    Names
    cytokine inducible SH2-containing protein 3
    cytokine-inducible SH2 protein 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053565.1NP_446017.1  suppressor of cytokine signaling 3

      See identical proteins and their annotated locations for NP_446017.1

      Status: PROVISIONAL

      Source sequence(s)
      AF075383
      UniProtKB/Swiss-Prot
      O88583
      Related
      ENSRNOP00000003940, ENSRNOT00000003940
      Conserved Domains (2) summary
      cd10384
      Location:35135
      SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03737
      Location:184225
      SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      106973863..106976969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768398.1XP_008766620.1  

      See identical proteins and their annotated locations for XP_008766620.1

      UniProtKB/TrEMBL
      G3V6D2
      Conserved Domains (2) summary
      cd10384
      Location:35135
      SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03737
      Location:184225
      SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      101756900..101757762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)