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    VASP vasodilator-stimulated phosphoprotein [ Homo sapiens (human) ]

    Gene ID: 7408, updated on 30-Jun-2015
    Official Symbol
    VASPprovided by HGNC
    Official Full Name
    vasodilator-stimulated phosphoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:12652
    See related
    Ensembl:ENSG00000125753; HPRD:03415; MIM:601703; Vega:OTTHUMG00000182124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]
    Orthologs
    See VASP in Epigenomics, MapViewer
    Location:
    19q13.32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (45507430..45526989)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46010688..46030247)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene reticulon 2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) Neighboring gene optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) Neighboring gene G protein-coupled receptor 4 Neighboring gene echinoderm microtubule associated protein like 2 Neighboring gene microRNA 330

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    profilin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    actin polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance TAS
    Traceable Author Statement
    more info
     
    cell junction assembly TAS
    Traceable Author Statement
    more info
     
    neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    vasodilator-stimulated phosphoprotein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003370.3NP_003361.1  vasodilator-stimulated phosphoprotein

      See identical proteins and their annotated locations for NP_003361.1

      Status: REVIEWED

      Source sequence(s)
      BC038224, BG751094, BG825983, Z46389
      Consensus CDS
      CCDS33051.1
      UniProtKB/TrEMBL
      A0A024R0V4
      UniProtKB/Swiss-Prot
      P50552
      Related
      ENSP00000245932, OTTHUMP00000268455, ENST00000245932, OTTHUMT00000459589
      Conserved Domains (2) summary
      pfam08776
      Location:340379
      VASP_tetra; VASP tetramerization domain
      cd01207
      Location:5113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

      Range
      45507430..45526989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259200.1XP_005259257.1  

      Conserved Domains (2) summary
      pfam08776
      Location:339378
      VASP_tetra; VASP tetramerization domain
      cd01207
      Location:5113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    2. XM_005259199.1XP_005259256.1  

      See identical proteins and their annotated locations for XP_005259256.1

      Conserved Domains (2) summary
      pfam08776
      Location:339378
      VASP_tetra; VASP tetramerization domain
      cd01207
      Location:5113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      46013932..46033484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008736.1: Suppressed sequence

      Description
      NM_001008736.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.