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TOM1 target of myb1 (chicken) [ Homo sapiens (human) ]

Gene ID: 10043, updated on 7-Dec-2014
Official Symbol
TOM1provided by HGNC
Official Full Name
target of myb1 (chicken)provided by HGNC
Primary source
HGNC:HGNC:11982
Locus tag
CTA-286B10.4
See related
Ensembl:ENSG00000100284; HPRD:05265; MIM:604700; Vega:OTTHUMG00000150958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
See TOM1 in Epigenomics, MapViewer
Location:
22q13.1
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 22 NC_000022.11 (35299275..35347994)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (35695268..35743987)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit VIIb pseudogene 1 Neighboring gene HMG box domain containing 4 Neighboring gene microRNA 3909 Neighboring gene microRNA 6069 Neighboring gene heme oxygenase (decycling) 1 Neighboring gene minichromosome maintenance complex component 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of target of myb1 (TOM1) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ33404

Gene Ontology Provided by GOA

Function Evidence Code Pubs
clathrin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endocytosis NAS
Non-traceable Author Statement
more info
PubMed 
endosomal transport NAS
Non-traceable Author Statement
more info
PubMed 
endosomal transport TAS
Traceable Author Statement
more info
PubMed 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
protein transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
target of Myb protein 1
Names
target of Myb protein 1
target of myb 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135729.1NP_001129201.1  target of Myb protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different 5' terminal exon and uses an alternate donor splice site at the penultimate exon compared to transcript variant 1. This results in translation initiation from a downstream AUG and an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AJ006973, AK097066, AK293694, R39075
    Consensus CDS
    CCDS46698.1
    UniProtKB/TrEMBL
    B3KUF5
    UniProtKB/Swiss-Prot
    O60784
    Related
    ENSP00000398876, ENST00000447733
    Conserved Domains (2) summary
    cd14236
    Location:181275
    GAT_TOM1; GAT domain found in target of Myb protein 1 (Tom1)
    cl02544
    Location:1119
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  2. NM_001135730.1NP_001129202.1  target of Myb protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is missing an in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (4) lacking an internal 45 aa segment compared to isoform 1.
    Source sequence(s)
    AJ006973, AK097066, DC297234, R39075
    Consensus CDS
    CCDS46697.1
    UniProtKB/TrEMBL
    B3KUF5
    UniProtKB/Swiss-Prot
    O60784
    Related
    ENSP00000394924, ENST00000425375
    Conserved Domains (2) summary
    cd14236
    Location:169263
    GAT_TOM1; GAT domain found in target of Myb protein 1 (Tom1)
    cl02544
    Location:12123
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  3. NM_001135732.1NP_001129204.1  target of Myb protein 1 isoform 2

    See proteins identical to NP_001129204.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon compared to transcript variant 1, resulting in an isoform (2) with one extra aa compared to isoform 1.
    Source sequence(s)
    AK097066, BC046151, DC297234, R39075
    Consensus CDS
    CCDS46696.1
    UniProtKB/TrEMBL
    B3KUF5
    UniProtKB/Swiss-Prot
    O60784
    Related
    ENSP00000413697, ENST00000411850
    Conserved Domains (2) summary
    cd03565
    Location:12152
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14236
    Location:214308
    GAT_TOM1; GAT domain found in target of Myb protein 1 (Tom1)
  4. NM_005488.2NP_005479.1  target of Myb protein 1 isoform 1

    See proteins identical to NP_005479.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the most predominant transcript and encodes isoform 1.
    Source sequence(s)
    AJ006973, AK097066, DC297234, R39075
    Consensus CDS
    CCDS13913.1
    UniProtKB/TrEMBL
    B3KUF5
    UniProtKB/Swiss-Prot
    O60784
    Related
    ENSP00000394466, OTTHUMP00000198803, ENST00000449058, OTTHUMT00000320641
    Conserved Domains (2) summary
    cd03565
    Location:12152
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14236
    Location:214308
    GAT_TOM1; GAT domain found in target of Myb protein 1 (Tom1)

RNA

  1. NR_024194.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate acceptor splice site at one of the coding exons compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense mediated mRNA decay (NMD). This variant is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because it is significantly truncated.
    Source sequence(s)
    AK097066, AK296670, DC297234, R39075
  2. NR_024195.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) is missing an internal coding exon and uses an alternate acceptor splice site at another coding exon compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense mediated mRNA decay (NMD). This variant is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because it is significantly truncated.
    Source sequence(s)
    AJ006973, AK097066, AK295918, DC297234, R39075

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000022.11 

    Range
    35299275..35347994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 

    Range
    35653446..35702167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000154.1 

    Range
    18656369..18704501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)