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Lamp2 lysosomal-associated membrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 16784, updated on 19-Jul-2014
Official Symbol
Lamp2provided by MGI
Official Full Name
lysosomal-associated membrane protein 2provided by MGI
Primary source
MGI:96748
Locus tag
RP23-193O17.2
See related
Ensembl:ENSMUSG00000016534; Vega:OTTMUSG00000017230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c
See Lamp2 in Epigenomics, MapViewer
Location:
X A3.3; X 22.67 cM
Exon count:
11
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) X NC_000086.7 (38401357..38456463, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 40 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene coiled-coil domain containing 94 pseudogene Neighboring gene predicted gene 9488

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
protein stabilization IMP
Inferred from Mutant Phenotype
more info
 
Component Evidence Code Pubs
endosome ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
late endosome membrane IDA
Inferred from Direct Assay
more info
 
late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
phagocytic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
platelet dense granule membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
lysosome-associated membrane glycoprotein 2
Names
lysosome-associated membrane glycoprotein 2
lysosomal membrane glycoprotein 2
CD107 antigen-like family member B
lysosomal membrane glycoprotein type B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017959.2NP_001017959.1  lysosome-associated membrane glycoprotein 2 isoform 1 precursor

    See proteins identical to NP_001017959.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK159272, AK163933, AL513356
    Consensus CDS
    CCDS30092.1
    UniProtKB/Swiss-Prot
    P17047
    Related
    ENSMUSP00000016678, OTTMUSP00000018801, ENSMUST00000016678, OTTMUST00000041813
    Conserved Domains (1) summary
    pfam01299
    Location:105415
    Blast Score: 924
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)
  2. NM_001290485.1NP_001277414.1  lysosome-associated membrane glycoprotein 2 isoform 3 precursor

    See proteins identical to NP_001277414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) is longer than isoform 1 and has a distinct C-terminus.
    Source sequence(s)
    AK078193, AK163933, BQ176100
    Consensus CDS
    CCDS72369.1
    UniProtKB/Swiss-Prot
    P17047
    UniProtKB/TrEMBL
    Q8C5K0
    Conserved Domains (1) summary
    pfam01299
    Location:105416
    Blast Score: 939
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)
  3. NM_010685.4NP_034815.2  lysosome-associated membrane glycoprotein 2 isoform 2 precursor

    See proteins identical to NP_034815.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is the same length as isoform 1 but has a distinct C-terminus.
    Source sequence(s)
    AK080234, AK163933, AL513356
    Consensus CDS
    CCDS30093.1
    UniProtKB/Swiss-Prot
    P17047
    Related
    ENSMUSP00000052283, OTTMUSP00000018739, ENSMUST00000061755, OTTMUST00000041711
    Conserved Domains (1) summary
    pfam01299
    Location:105415
    Blast Score: 975
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000086.7 

    Range
    38401357..38456463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541430.1XP_006541493.1  

    Related
    ENSMUSP00000074448, OTTMUSP00000018802, ENSMUST00000074913, OTTMUST00000041814
    Conserved Domains (1) summary
    pfam01299
    Location:105416
    Blast Score: 939
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

Alternate Mm_Celera

Genomic

  1. AC_000042.1 

    Range
    26051798..26103095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)