Display Settings:

Format

Send to:

Choose Destination

Fadd Fas (TNFRSF6)-associated via death domain [ Mus musculus (house mouse) ]

Gene ID: 14082, updated on 7-Aug-2014
Official Symbol
Faddprovided by MGI
Official Full Name
Fas (TNFRSF6)-associated via death domainprovided by MGI
Primary source
MGI:109324
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mort1/FADD
See Fadd in Epigenomics, MapViewer
Location:
7 F5; 7 88.85 cM
Exon count:
2
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 7 NC_000073.6 (144578323..144582436, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene cortactin Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Neighboring gene uncharacterized LOC102639278 Neighboring gene anoctamin 1, calcium activated chloride channel Neighboring gene uncharacterized LOC102638316 Neighboring gene RIKEN cDNA D930030F02 gene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
death effector domain binding ISO
Inferred from Sequence Orthology
more info
 
death receptor binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor receptor superfamily binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell differentiation TAS
Traceable Author Statement
more info
PubMed 
T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
 
T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 
TRAIL-activated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
defense response to virus ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
lymph node development IGI
Inferred from Genetic Interaction
more info
 
motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of necroptotic process IGI
Inferred from Genetic Interaction
more info
 
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of adaptive immune response IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 
positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
spleen development IGI
Inferred from Genetic Interaction
more info
 
thymus development IGI
Inferred from Genetic Interaction
more info
 
Component Evidence Code Pubs
CD95 death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
cell body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
ripoptosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
FAS-associated death domain protein
Names
FAS-associated death domain protein
protein FADD
mediator of receptor induced toxicity
Fas-associating protein with death domain
FAS-associating death domain-containing protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010175.5NP_034305.1  FAS-associated death domain protein

    See proteins identical to NP_034305.1

    Status: PROVISIONAL

    Source sequence(s)
    AC153792
    Consensus CDS
    CCDS22050.1
    UniProtKB/Swiss-Prot
    Q61160
    Conserved Domains (2) summary
    cd08306
    Location:97181
    Blast Score: 338
    Death_FADD; Fas-associated Death Domain protein-protein interaction domain
    cd08336
    Location:283
    Blast Score: 210
    DED_FADD; Death Effector Domain found in Fas-Associated via Death Domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000073.6 

    Range
    144578323..144582436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000029.1 

    Range
    144342191..144346305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)