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    Plg plasminogen [ Mus musculus (house mouse) ]

    Gene ID: 18815, updated on 9-Aug-2016
    Official Symbol
    Plgprovided by MGI
    Official Full Name
    plasminogenprovided by MGI
    Primary source
    MGI:MGI:97620
    See related
    Ensembl:ENSMUSG00000059481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pg; AI649309
    Orthologs
    Location:
    17 A1; 17 8.5 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (12378609..12419384)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (12571475..12612250)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene serologically defined colon cancer antigen 3 pseudogene Neighboring gene predicted gene, 41527 Neighboring gene solute carrier family 22 (organic cation transporter), member 3 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene RIKEN cDNA C030013G03 gene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
     
    hemostasis IEA
    Inferred from Electronic Annotation
    more info
     
    labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mononuclear cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis involved in cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    trophoblast giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    blood microparticle ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    plasminogen
    Names
    angiostatin
    plasmin heavy chain A
    plasmin light chain B
    NP_032903.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008877.3NP_032903.3  plasminogen precursor

      See identical proteins and their annotated locations for NP_032903.3

      Status: VALIDATED

      Source sequence(s)
      AK132254, BY131661, J04766
      Consensus CDS
      CCDS28390.1
      UniProtKB/Swiss-Prot
      P20918
      UniProtKB/TrEMBL
      Q3V1T9
      Related
      ENSMUSP00000014578, ENSMUST00000014578
      Conserved Domains (4) summary
      smart00020
      Location:581805
      Tryp_SPc; Trypsin-like serine protease
      cd00108
      Location:273353
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00190
      Location:582807
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cd01099
      Location:3897
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      12378609..12419384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)