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    Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 18706, updated on 23-Aug-2016
    Official Symbol
    Pik3caprovided by MGI
    Official Full Name
    phosphatidylinositol 3-kinase, catalytic, alpha polypeptideprovided by MGI
    Primary source
    MGI:MGI:1206581
    See related
    Ensembl:ENSMUSG00000027665 Vega:OTTMUSG00000021191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p110; caPI3K; p110alpha; 6330412C24Rik
    Orthologs
    Location:
    3 15.7 cM; 3 B
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (32397069..32468486)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (32335073..32367408)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene zinc finger matrin type 3 Neighboring gene RIKEN cDNA 4930429B21 gene Neighboring gene predicted gene, 42202 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 3 Neighboring gene zinc finger protein 639 Neighboring gene mitofusin 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC161268

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    1-phosphatidylinositol-3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    1-phosphatidylinositol-3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor substrate binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hypomethylation of CpG island IDA
    Inferred from Direct Assay
    more info
    PubMed 
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitophagy in response to mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of genetic imprinting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol 3-kinase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatidylinositol 3-kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase complex, class IA ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Names
    PI3-kinase subunit alpha
    PI3K-alpha
    PI3Kalpha
    phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
    phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    phosphoinositide-3-kinase catalytic alpha polypeptide
    ptdIns-3-kinase subunit alpha
    ptdIns-3-kinase subunit p110-alpha
    serine/threonine protein kinase PIK3CA
    NP_032865.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008839.2NP_032865.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

      See identical proteins and their annotated locations for NP_032865.2

      Status: VALIDATED

      Source sequence(s)
      AC130281, BC089038
      Consensus CDS
      CCDS38409.1
      UniProtKB/Swiss-Prot
      P42337
      Related
      ENSMUSP00000029201, ENSMUST00000029201
      Conserved Domains (5) summary
      cd08398
      Location:325484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:31108
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:173292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:6951064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      32397069..32468486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535409.3XP_006535472.1  

      See identical proteins and their annotated locations for XP_006535472.1

      UniProtKB/Swiss-Prot
      P42337
      Conserved Domains (5) summary
      cd08398
      Location:325484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:31108
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:173292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:6951064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
    2. XM_006535410.3XP_006535473.1  

      See identical proteins and their annotated locations for XP_006535473.1

      UniProtKB/Swiss-Prot
      P42337
      Related
      ENSMUSP00000103878, OTTMUSP00000023403, ENSMUST00000108243, OTTMUST00000050202
      Conserved Domains (5) summary
      cd08398
      Location:325484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:31108
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:173292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:6951064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha