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    LEF1 lymphoid enhancer-binding factor 1 [ Homo sapiens (human) ]

    Gene ID: 51176, updated on 24-Aug-2015
    Official Symbol
    LEF1provided by HGNC
    Official Full Name
    lymphoid enhancer-binding factor 1provided by HGNC
    Primary source
    HGNC:HGNC:6551
    See related
    Ensembl:ENSG00000138795; HPRD:01075; MIM:153245; Vega:OTTHUMG00000131809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LEF-1; TCF10; TCF7L3; TCF1ALPHA
    Summary
    This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
    Orthologs
    See LEF1 in Epigenomics, MapViewer
    Location:
    4q23-q25
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (108047545..108168956, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (108968701..109090112, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929595 Neighboring gene cytochrome P450, family 2, subfamily U, polypeptide 1 Neighboring gene hydroxyacyl-CoA dehydrogenase Neighboring gene LEF1 antisense RNA 1 Neighboring gene zinc-activated ligand-gated ion channel-like Neighboring gene ribosomal protein SA pseudogene 34 Neighboring gene exocyst complex component 7 pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.
    NHGRI GWA Catalog
    Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
    NHGRI GWA Catalog
    Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat and methamphetamine suppresses expression of LEF-1, a key partner of beta-catenin to regulate cognate gene expression PubMed

    Go to the HIV-1, Human Interaction Database

    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Arrhythmogenic right ventricular cardiomyopathy, organism-specific biosystem (from WikiPathways)
      Arrhythmogenic right ventricular cardiomyopathy, organism-specific biosystemAdapted from KEGG: http://www.genome.jp/kegg/pathway/hsa/hsa05412.html
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Ca2+ pathway, organism-specific biosystem (from REACTOME)
      Ca2+ pathway, organism-specific biosystemA number of so called non-canonical WNT ligands have been shown to promote intracellular calcium release upon FZD binding. This beta-catenin-independent WNT pathway acts through heterotrimeric G pro...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
      Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Melanogenesis, organism-specific biosystem (from KEGG)
      Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melanogenesis, conserved biosystem (from KEGG)
      Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
    • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
      TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
    • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Thyroid cancer, organism-specific biosystem (from KEGG)
      Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid cancer, conserved biosystem (from KEGG)
      Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
    • Wnt signaling, organism-specific biosystem (from KEGG)
      Wnt signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Wnt signaling, conserved biosystem (from KEGG)
      Wnt signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
      beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
    • binding of TCF/LEF:CTNNB1 to target gene promoters, organism-specific biosystem (from REACTOME)
      binding of TCF/LEF:CTNNB1 to target gene promoters, organism-specific biosystemThe genes regulated by beta-catenin and TCF/LEF are involved in a diverse range of functions in cellular proliferation, differentiation, embryogenesis and tissue homeostasis, and include transcriptio...
    • deactivation of the beta-catenin transactivating complex, organism-specific biosystem (from REACTOME)
      deactivation of the beta-catenin transactivating complex, organism-specific biosystemThe mechanisms involved in downregulation of TCF-dependent transcription are not yet very well understood. beta-catenin is known to recruit a number of transcriptional repressors, including Reptin, S...
    • formation of the beta-catenin:TCF transactivating complex, organism-specific biosystem (from REACTOME)
      formation of the beta-catenin:TCF transactivating complex, organism-specific biosystemOnce in the nucleus, beta-catenin is recruited to WNT target genes through interaction with TCF/LEF transcription factors. This family, which consists of TCF7 (also known as TCF1), TCF7L1 (also known...
    • repression of WNT target genes, organism-specific biosystem (from REACTOME)
      repression of WNT target genes, organism-specific biosystemIn the absence of a WNT signal, many WNT target genes are repressed by Groucho/TLE. Groucho was initially identified in Drosophila, where it has been shown to interact with a variety of proteins to ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ46390, DKFZp586H0919

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C2H2 zinc finger domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA binding, bending ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    armadillo repeat domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enhancer binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    estrogen receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    estrogen receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gamma-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    T cell receptor V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
     
    T-helper 1 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alpha-beta T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    anatomical structure regression IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process involved in morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apoptotic process involved in patterning of blood vessels IEA
    Inferred from Electronic Annotation
    more info
     
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to cytokine stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chorio-allantoic fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dentate gyrus development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    embryonic limb morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    epithelial to mesenchymal transition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    eye pigmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    face morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    forebrain neuroblast division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    forebrain neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    forebrain radial glial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    formation of radial glial scaffolds IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    generation of neurons IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    histone H3 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H4 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hypothalamus development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    muscle fiber development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process in bone marrow IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of estrogen receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-13 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-4 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-5 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of striated muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neutrophil differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    odontoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    palate development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    paraxial mesoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    patterning of blood vessels IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation by host of viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell cycle process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation in bone marrow IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of granulocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of striated muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
     
    skin development IEA
    Inferred from Electronic Annotation
    more info
     
    somitogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    steroid hormone mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tongue development IEA
    Inferred from Electronic Annotation
    more info
     
    trachea gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    lymphoid enhancer-binding factor 1
    Names
    T cell-specific transcription factor 1-alpha
    TCF1-alpha

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015798.1 RefSeqGene

      Range
      5001..126412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130713.2NP_001124185.1  lymphoid enhancer-binding factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001124185.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC097067, AC118062, AF288571, AK225772, AL049409
      Consensus CDS
      CCDS47123.1
      UniProtKB/TrEMBL
      Q659G9
      UniProtKB/Swiss-Prot
      Q9UJU2
      Conserved Domains (2) summary
      cd01388
      Location:270341
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1213
      CTNNB1_binding; N-terminal CTNNB1 binding
    2. NM_001130714.2NP_001124186.1  lymphoid enhancer-binding factor 1 isoform 3

      See identical proteins and their annotated locations for NP_001124186.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks both an in-frame exon in the central coding region and an exon in the 3' coding region that causes a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC097067, AF288571, AK225772, AL049409, BC040559
      Consensus CDS
      CCDS47122.1
      UniProtKB/TrEMBL
      Q659G9
      UniProtKB/Swiss-Prot
      Q9UJU2
      Related
      ENSP00000369284, ENST00000379951
      Conserved Domains (2) summary
      cd01388
      Location:270341
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1213
      CTNNB1_binding; N-terminal CTNNB1 binding
    3. NM_001166119.1NP_001159591.1  lymphoid enhancer-binding factor 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC118062, AF288571, AK303272, AL049409, DC405840, DC406065
      Consensus CDS
      CCDS54791.1
      UniProtKB/TrEMBL
      Q659G9
      UniProtKB/Swiss-Prot
      Q9UJU2
      Conserved Domains (2) summary
      cd01388
      Location:202273
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:3145
      CTNNB1_binding; N-terminal CTNNB1 binding
    4. NM_016269.4NP_057353.1  lymphoid enhancer-binding factor 1 isoform 1

      See identical proteins and their annotated locations for NP_057353.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC097067, AF288571, AK225772, AL049409, BC050632
      Consensus CDS
      CCDS3679.1
      UniProtKB/TrEMBL
      A0A024RDI7
      UniProtKB/TrEMBL
      Q659G9
      UniProtKB/Swiss-Prot
      Q9UJU2
      Related
      ENSP00000265165, OTTHUMP00000162624, ENST00000265165, OTTHUMT00000254749
      Conserved Domains (2) summary
      cd01388
      Location:298369
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1213
      CTNNB1_binding; N-terminal CTNNB1 binding

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      108047545..108168956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263046.2XP_005263103.1  

      Conserved Domains (2) summary
      cd01388
      Location:298369
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1213
      CTNNB1_binding; N-terminal CTNNB1 binding
    2. XM_006714233.1XP_006714296.1  

      Conserved Domains (2) summary
      cd01388
      Location:183254
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:598
      CTNNB1_binding; N-terminal CTNNB1 binding
    3. XM_005263048.1XP_005263105.1  

      Conserved Domains (2) summary
      cd01388
      Location:202273
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:3145
      CTNNB1_binding; N-terminal CTNNB1 binding
    4. XM_005263047.1XP_005263104.1  

      Conserved Domains (2) summary
      cd01388
      Location:230301
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:3145
      CTNNB1_binding; N-terminal CTNNB1 binding

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      108945152..109066566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)