Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    Shox2 short stature homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 20429, updated on 30-Jul-2015
    Official Symbol
    Shox2provided by MGI
    Official Full Name
    short stature homeobox 2provided by MGI
    Primary source
    MGI:MGI:1201673
    See related
    Ensembl:ENSMUSG00000027833; Vega:OTTMUSG00000042120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OG12; Prx3; SHOT; Og12x; 6330543G17Rik
    Orthologs
    See Shox2 in Epigenomics, MapViewer
    Location:
    3 30.76 cM; 3 E3-F1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (66971723..66981771, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (66777188..66785693, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 pseudogene Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 pseudogene Neighboring gene arginine/serine-rich coiled-coil 1 Neighboring gene myeloid leukemia factor 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cardiac atrium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cartilage development involved in endochondral bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic skeletal joint morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart valve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of branching morphogenesis of a nerve IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    short stature homeobox protein 2
    Names
    OG-12
    homeobox protein Og12X
    paired family homeodomain protein Prx3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302357.1NP_001289286.1  short stature homeobox protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC122870, AK032007, BB363478
      UniProtKB/Swiss-Prot
      P70390
      Related
      ENSMUSP00000029422, OTTMUSP00000048652, ENSMUST00000029422, OTTMUST00000089115
      Conserved Domains (2) summary
      cd00086
      Location:141199
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03826
      Location:296316
      OAR; OAR domain
    2. NM_001302358.1NP_001289287.1  short stature homeobox protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001289287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a downstream alternate 5'-terminal exon and uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AA509933, AC122870, AK032007, BB363478
      Consensus CDS
      CCDS79922.1
      UniProtKB/Swiss-Prot
      P70390
      Conserved Domains (2) summary
      cd00086
      Location:1270
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03826
      Location:167187
      OAR; OAR domain
    3. NM_001302359.1NP_001289288.1  short stature homeobox protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001289288.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a downstream alternate 5'-terminal exon and uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC122870, AK032007
      Consensus CDS
      CCDS79922.1
      UniProtKB/Swiss-Prot
      P70390
      Related
      ENSMUSP00000124924, OTTMUSP00000048713, ENSMUST00000162439, OTTMUST00000089218
      Conserved Domains (2) summary
      cd00086
      Location:1270
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03826
      Location:167187
      OAR; OAR domain
    4. NM_013665.1NP_038693.1  short stature homeobox protein 2 isoform 1

      See identical proteins and their annotated locations for NP_038693.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      U66918
      Consensus CDS
      CCDS17393.1
      UniProtKB/Swiss-Prot
      P70390
      Conserved Domains (2) summary
      cd00086
      Location:141199
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03826
      Location:308328
      OAR; OAR domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

      Range
      66971723..66981771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501215.2XP_006501278.1  

      See identical proteins and their annotated locations for XP_006501278.1

      Conserved Domains (2) summary
      cd00086
      Location:1270
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03826
      Location:179199
      OAR; OAR domain
    2. XM_006501216.1XP_006501279.1  

      See identical proteins and their annotated locations for XP_006501279.1

      Conserved Domains (2) summary
      cd00086
      Location:1270
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03826
      Location:179199
      OAR; OAR domain
    3. XM_006501217.2XP_006501280.1  

      See identical proteins and their annotated locations for XP_006501280.1

      Conserved Domains (2) summary
      cd00086
      Location:1270
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03826
      Location:179199
      OAR; OAR domain

    Alternate Mm_Celera

    Genomic

    1. AC_000025.1 Alternate Mm_Celera

      Range
      67107372..67117391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)