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    SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 [ Homo sapiens (human) ]

    Gene ID: 1468, updated on 5-Jul-2015
    Official Symbol
    SLC25A10provided by HGNC
    Official Full Name
    solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10provided by HGNC
    Primary source
    HGNC:HGNC:10980
    See related
    Ensembl:ENSG00000183048; HPRD:08424; MIM:606794; Vega:OTTHUMG00000178173
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIC
    Summary
    This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
    Orthologs
    See SLC25A10 in Epigenomics, MapViewer
    Location:
    17q25.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (81712236..81721016)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79679266..79688046)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene hepatocyte growth factor-regulated tyrosine kinase substrate Neighboring gene microRNA 6786 Neighboring gene mitochondrial ribosomal protein L12 Neighboring gene uncharacterized LOC105371929 Neighboring gene uncharacterized LOC105376789 Neighboring gene glucagon receptor

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association scan of dental caries in the permanent dentition.
    NHGRI GWA Catalog
    • Degradation of cysteine and homocysteine, organism-specific biosystem (from REACTOME)
      Degradation of cysteine and homocysteine, organism-specific biosystemWhile in humans excess methionine is converted to homocysteine, homocysteine and its transsulfuration product cysteine can be degraded to several end products, two of which, taurine and hydrogen sulf...
    • Gluconeogenesis, organism-specific biosystem (from REACTOME)
      Gluconeogenesis, organism-specific biosystemThe reactions of gluconeogenesis convert mitochondrial pyruvate to cytosolic glucose 6-phosphate which in turn can be hydrolyzed to glucose and exported from the cell. Gluconeogenesis is confined to ...
    • Glucose metabolism, organism-specific biosystem (from REACTOME)
      Glucose metabolism, organism-specific biosystemGlucose is the major form in which dietary sugars are made available to cells of the human body. Its breakdown is a major source of energy for all cells, and is essential for the brain and red blood ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
      Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
    • Organic anion transporters, organism-specific biosystem (from REACTOME)
      Organic anion transporters, organism-specific biosystemThe SLC17 gene family encode proteins which are organic anion transporters. There are three distinct subfamilies within SLC17; vesicular glutamate transporters (VGLUT1-3 encoded by SLC17A7,6 and 8), ...
    • Proximal tubule bicarbonate reclamation, organism-specific biosystem (from KEGG)
      Proximal tubule bicarbonate reclamation, organism-specific biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
    • Proximal tubule bicarbonate reclamation, conserved biosystem (from KEGG)
      Proximal tubule bicarbonate reclamation, conserved biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • Sulfide oxidation to sulfate, organism-specific biosystem (from REACTOME)
      Sulfide oxidation to sulfate, organism-specific biosystemWhile the human body is very economical with sulfur amino acids (SAA), superfluous SAA are degraded via cysteine to toxic hydrogen sulfide which must be dealt with. The pathway to oxidize this gas is...
    • Sulfur amino acid metabolism, organism-specific biosystem (from REACTOME)
      Sulfur amino acid metabolism, organism-specific biosystemThe main sulfur amino acids are methionine, cysteine, homocysteine and taurine. Of these, the first two are proteinogenic.This group of reactions contains all processes that 1) break down sulfur amin...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
      Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemTeleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    dicarboxylic acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
     
    cellular nitrogen compound metabolic process TAS
    Traceable Author Statement
    more info
     
    dicarboxylic acid transport TAS
    Traceable Author Statement
    more info
    PubMed 
    gluconeogenesis TAS
    Traceable Author Statement
    more info
     
    glucose metabolic process TAS
    Traceable Author Statement
    more info
     
    ion transport TAS
    Traceable Author Statement
    more info
     
    mitochondrial transport IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    sulfide oxidation, using sulfide:quinone oxidoreductase TAS
    Traceable Author Statement
    more info
     
    sulfur amino acid catabolic process TAS
    Traceable Author Statement
    more info
     
    sulfur amino acid metabolic process TAS
    Traceable Author Statement
    more info
     
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    mitochondrial dicarboxylate carrier
    Names
    dicarboxylate ion carrier

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270888.1NP_001257817.1  mitochondrial dicarboxylate carrier isoform 1

      See identical proteins and their annotated locations for NP_001257817.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC139530, AI081980, BC015797, HY259124
      Consensus CDS
      CCDS59301.1
      UniProtKB/Swiss-Prot
      Q9UBX3
      Related
      ENSP00000328403, OTTHUMP00000258682, ENST00000331531, OTTHUMT00000440815
      Conserved Domains (2) summary
      PTZ00169
      Location:13288
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:95191
      Mito_carr; Mitochondrial carrier protein
    2. NM_001270953.1NP_001257882.1  mitochondrial dicarboxylate carrier isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AC139530, AI081980, BC007355, BM561945, HY259124
      Consensus CDS
      CCDS74176.1
      UniProtKB/TrEMBL
      F6RGN5
      UniProtKB/Swiss-Prot
      Q9UBX3
      Related
      ENSP00000446242, ENST00000545862
      Conserved Domains (1) summary
      pfam00153
      Location:1393
      Mito_carr; Mitochondrial carrier protein
    3. NM_012140.4NP_036272.2  mitochondrial dicarboxylate carrier isoform 2

      See identical proteins and their annotated locations for NP_036272.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC139530, AI081980, BC007355, HY259124
      Consensus CDS
      CCDS11786.1
      UniProtKB/Swiss-Prot
      Q9UBX3
      Related
      ENSP00000345580, OTTHUMP00000258683, ENST00000350690, OTTHUMT00000440816
      Conserved Domains (2) summary
      PTZ00169
      Location:13279
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:196284
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      81712236..81721016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257074.2XP_005257131.1  

      See identical proteins and their annotated locations for XP_005257131.1

      UniProtKB/TrEMBL
      B4E1E9
      Conserved Domains (1) summary
      pfam00153
      Location:153241
      Mito_carr; Mitochondrial carrier protein

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      79765485..79774259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)