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    F8 coagulation factor VIII [ Mus musculus (house mouse) ]

    Gene ID: 14069, updated on 25-Jul-2015
    Official Symbol
    F8provided by MGI
    Official Full Name
    coagulation factor VIIIprovided by MGI
    Primary source
    MGI:MGI:88383
    See related
    Ensembl:ENSMUSG00000031196; Vega:OTTMUSG00000020850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cf8; Cf-8; FVIII
    Orthologs
    Location:
    X 38.17 cM; X A7-B
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (75172715..75383525, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (72418054..72625380, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 14B pseudogene Neighboring gene predicted pseudogene 6036 Neighboring gene small integral membrane protein 9 Neighboring gene protein phosphatase 4, regulatory subunit 2 pseudogene Neighboring gene predicted gene 8522 Neighboring gene FUN14 domain containing 2 Neighboring gene mature T cell proliferation 1 Neighboring gene BRCA1/BRCA2-containing complex, subunit 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    blood coagulation, intrinsic pathway ISO
    Inferred from Sequence Orthology
    more info
     
    hemostasis IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    coagulation factor VIII
    Names
    Factor VIII
    procoagulant component

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161373.1NP_001154845.1  coagulation factor VIII isoform 2 precursor

      See identical proteins and their annotated locations for NP_001154845.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK051579, AW489638, BC138347
      Consensus CDS
      CCDS53114.1
      UniProtKB/TrEMBL
      B2RRC9
      UniProtKB/TrEMBL
      Q8BQ43
      Related
      ENSMUSP00000109719, ENSMUST00000114085
      Conserved Domains (3) summary
      cd00057
      Location:20942242
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:399575
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:22202
      Cupredoxin; Cupredoxin superfamily
    2. NM_001161374.1NP_001154846.1  coagulation factor VIII isoform 3 precursor

      See identical proteins and their annotated locations for NP_001154846.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK051579, AW489638, BC145245
      UniProtKB/TrEMBL
      B7ZNH8
      UniProtKB/TrEMBL
      Q8BQ43
      Conserved Domains (3) summary
      cd00057
      Location:20942240
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:399575
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:22202
      Cupredoxin; Cupredoxin superfamily
    3. NM_007977.2NP_032003.2  coagulation factor VIII isoform 1 precursor

      See identical proteins and their annotated locations for NP_032003.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK051579, AW489638, BC138347, L05573
      Consensus CDS
      CCDS30238.1
      UniProtKB/TrEMBL
      B2RRC9
      UniProtKB/Swiss-Prot
      Q06194
      UniProtKB/TrEMBL
      Q8BQ43
      Conserved Domains (3) summary
      cd00057
      Location:21642312
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:399575
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:22202
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

      Range
      75172715..75383525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527789.2XP_006527852.1  

      Related
      ENSMUSP00000033539, OTTMUSP00000022815, ENSMUST00000033539, OTTMUST00000049293
      Conserved Domains (3) summary
      cd00057
      Location:21642310
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:399575
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:22202
      Cupredoxin; Cupredoxin superfamily
    2. XM_006527790.2XP_006527853.1  

      Conserved Domains (3) summary
      cd00057
      Location:21572305
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:392568
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:15195
      Cupredoxin; Cupredoxin superfamily
    3. XM_006527791.2XP_006527854.1  

      See identical proteins and their annotated locations for XP_006527854.1

      Conserved Domains (3) summary
      cd00057
      Location:21112259
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:346522
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:16311795
      Cupredoxin; Cupredoxin superfamily
    4. XM_006527792.2XP_006527855.1  

      See identical proteins and their annotated locations for XP_006527855.1

      Conserved Domains (3) summary
      cd00057
      Location:21112259
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:346522
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:16311795
      Cupredoxin; Cupredoxin superfamily

    Alternate Mm_Celera

    Genomic

    1. AC_000042.1 Alternate Mm_Celera

      Range
      66576966..66780957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)