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Sqstm1 sequestosome 1 [ Mus musculus (house mouse) ]

Gene ID: 18412, updated on 23-Nov-2014
Official Symbol
Sqstm1provided by MGI
Official Full Name
sequestosome 1provided by MGI
Primary source
MGI:MGI:107931
Locus tag
RP23-319B15.3
See related
Ensembl:ENSMUSG00000015837; Vega:OTTMUSG00000005574
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Osi; p62; A170; STAP; OSF-6; STONE14
See Sqstm1 in Epigenomics, MapViewer
Location:
11; 11 B1.2
Exon count:
8
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (50200152..50210998, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 9B Neighboring gene RIKEN cDNA 3010026O09 gene Neighboring gene predicted gene, 36556 Neighboring gene mannoside acetylglucosaminyltransferase 4, isoenzyme B Neighboring gene microRNA 6919

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
K63-linked polyubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
transcription cofactor activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
autophagy ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of nucleic acid-templated transcription TAS
Traceable Author Statement
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
PML body ISO
Inferred from Sequence Orthology
more info
 
aggresome IDA
Inferred from Direct Assay
more info
PubMed 
autophagic vacuole IBA
Inferred from Biological aspect of Ancestor
more info
 
autophagic vacuole ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic mRNA processing body ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
inclusion body ISO
Inferred from Sequence Orthology
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
pre-autophagosomal structure IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
sequestosome-1
Names
sequestosome-1
oxidative stress induced
ubiquitin-binding protein p62

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290769.1NP_001277698.1  sequestosome-1 isoform 2

    See proteins identical to NP_001277698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region but maintains reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK028898, BY267273
    Consensus CDS
    CCDS70176.1
    UniProtKB/Swiss-Prot
    Q64337
    Conserved Domains (3) summary
    cd06402
    Location:5102
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd00194
    Location:358393
    UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
    cd02340
    Location:126166
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
  2. NM_011018.3NP_035148.1  sequestosome-1 isoform 1

    See proteins identical to NP_035148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK028898, BY267273, CX240486
    Consensus CDS
    CCDS24629.1
    UniProtKB/Swiss-Prot
    Q64337
    Related
    ENSMUSP00000099835, OTTMUSP00000005736, ENSMUST00000102774, OTTMUST00000012391
    Conserved Domains (3) summary
    cd06402
    Location:5102
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd00194
    Location:396431
    UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
    cd02340
    Location:126166
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    50200152..50210998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532450.1XP_006532513.1  

    Conserved Domains (3) summary
    cd06402
    Location:5102
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd00194
    Location:358393
    UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
    cd02340
    Location:126166
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    54760561..54771199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)