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KDM5B lysine (K)-specific demethylase 5B [ Homo sapiens (human) ]

Gene ID: 10765, updated on 19-Jul-2014
Official Symbol
KDM5Bprovided by HGNC
Official Full Name
lysine (K)-specific demethylase 5Bprovided by HGNC
Primary source
HGNC:18039
See related
Ensembl:ENSG00000117139; HPRD:09251; MIM:605393; Vega:OTTHUMG00000041401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT31; PLU1; PUT1; PLU-1; JARID1B; PPP1R98; RBBP2H1A
See KDM5B in Epigenomics, MapViewer
Location:
1q32.1
Exon count :
27
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (202727404..202808421, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202696532..202777549, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 12B Neighboring gene ribosomal protein S27 pseudogene 8 Neighboring gene uncharacterized LOC101926929 Neighboring gene synaptotagmin II Neighboring gene cytochrome c oxidase subunit VIIc pseudogene Neighboring gene uncharacterized LOC102723494 Neighboring gene solute carrier family 25, member 39 pseudogene 1 Neighboring gene prostate cancer associated transcript 6 (non-protein coding)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of lysine (K)-specific demethylase 5B (KDM5B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
histone H3-K4 demethylation IDA
Inferred from Direct Assay
more info
 
histone H3-K4 demethylation, trimethyl-H3-K4-specific IDA
Inferred from Direct Assay
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
lysine-specific demethylase 5B
Names
lysine-specific demethylase 5B
RBP2-H1
cancer/testis antigen 31
histone demethylase JARID1B
putative DNA/chromatin binding motif
jumonji, AT rich interactive domain 1B
jumonji/ARID domain-containing protein 1B
retinoblastoma-binding protein 2 homolog 1
protein phosphatase 1, regulatory subunit 98
retinoblastoma-binding protein 2, homolog 1A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006618.3NP_006609.3  lysine-specific demethylase 5B

    See proteins identical to NP_006609.3

    Status: VALIDATED

    Source sequence(s)
    AJ132440, AL133040, CF593335
    Consensus CDS
    CCDS30974.1
    UniProtKB/TrEMBL
    Q9UFD3
    UniProtKB/Swiss-Prot
    Q9UGL1
    Related
    ENSP00000356234, OTTHUMP00000038815, ENST00000367265, OTTHUMT00000099184
    Conserved Domains (6) summary
    smart00545
    Location:3172
    Blast Score: 202
    JmjN; Small domain found in the jumonji family of transcription factors
    pfam02373
    Location:486602
    Blast Score: 461
    JmjC; JmjC domain, hydroxylase
    pfam00628
    Location:311356
    Blast Score: 164
    PHD; PHD-finger
    pfam01388
    Location:94183
    Blast Score: 303
    ARID; ARID/BRIGHT DNA binding domain
    pfam02928
    Location:692745
    Blast Score: 237
    zf-C5HC2; C5HC2 zinc finger
    pfam08429
    Location:7561088
    Blast Score: 921
    PLU-1; PLU-1-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    202727404..202808421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    173862355..173943136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    204118752..204199788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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