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    NCAPD2 non-SMC condensin I complex, subunit D2 [ Homo sapiens (human) ]

    Gene ID: 9918, updated on 5-Jul-2015
    Official Symbol
    NCAPD2provided by HGNC
    Official Full Name
    non-SMC condensin I complex, subunit D2provided by HGNC
    Primary source
    HGNC:HGNC:24305
    See related
    Ensembl:ENSG00000010292; HPRD:06472; MIM:615638; Vega:OTTHUMG00000168513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNAP1; CAP-D2; hCAP-D2
    Orthologs
    See NCAPD2 in Epigenomics, MapViewer
    Location:
    12p13.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (6494132..6531966)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6602547..6641132)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene plakophilin 2 pseudogene 1 Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene small Cajal body-specific RNA 10 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase Neighboring gene intermediate filament family orphan 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of HIV-1 Tat with CAPD2 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed

    Go to the HIV-1, Human Interaction Database

    • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora B signaling, organism-specific biosystem
      Aurora B signaling
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Condensation of Prometaphase Chromosomes, organism-specific biosystem (from REACTOME)
      Condensation of Prometaphase Chromosomes, organism-specific biosystemThe condensin I complex is evolutionarily conserved and consists of five subunits: two SMC (structural maintenance of chromosomes) family subunits, SMC2 and SMC4, and three non-SMC subunits, NCAPD2, ...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0159

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    meiotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    mitotic chromosome condensation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic chromosome condensation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    condensin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensin core heterodimer NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    condensin complex subunit 1
    Names
    XCAP-D2 homolog
    chromosome condensation related SMC associated protein 1
    chromosome condensation-related SMC-associated protein 1
    chromosome-associated protein D2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014865.3NP_055680.3  condensin complex subunit 1

      See identical proteins and their annotated locations for NP_055680.3

      Status: VALIDATED

      Source sequence(s)
      AK022511, AK128354, AL548223, BC028182, CN307514, D63880
      Consensus CDS
      CCDS8548.1
      UniProtKB/TrEMBL
      B3KMS0
      UniProtKB/TrEMBL
      B3KY03
      UniProtKB/Swiss-Prot
      Q15021
      Related
      ENSP00000325017, OTTHUMP00000238893, ENST00000315579, OTTHUMT00000399964
      Conserved Domains (2) summary
      COG5098
      Location:601245
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12922
      Location:74241
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

      Range
      6494132..6531966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      6602311..6640139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)