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    ARF6 ADP ribosylation factor 6 [ Homo sapiens (human) ]

    Gene ID: 382, updated on 23-Apr-2016
    Official Symbol
    ARF6provided by HGNC
    Official Full Name
    ADP ribosylation factor 6provided by HGNC
    Primary source
    HGNC:HGNC:659
    See related
    Ensembl:ENSG00000165527 HPRD:02714; MIM:600464; Vega:OTTHUMG00000140296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    14q21.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (49893018..49897054)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (50359736..50363772)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378179 Neighboring gene RNA, 7SL, cytoplasmic 3 Neighboring gene RNA, 7SL, cytoplasmic 2 Neighboring gene uncharacterized LOC100506446 Neighboring gene microRNA 6076

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of ADP-ribosylation factor 6 (ARF6) by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 6 (ARF6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Envelope surface glycoprotein gp160, precursor env GDP-bound or GTP-bound inactive Arf6 mutants or siRNA-mediated Arf6 silencing inhibit HIV-1 envelope-induced membrane fusion, entry, and infection of T lymphocytes and permissive cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 6 (ARF6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 6 (ARF6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    nef ARF6(T27N) and ARF6(Q67L) mutants induce significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane PubMed
    nef The interaction of HIV-1 Nef and phosphatidylinositol-3-kinase (PI3K) activates the expression of ADP-ribosylation factor 6 (ARF6) in human melanoma cells PubMed
    nef HIV-1 Nef-mediated downregulation of MHC-I has been reported to be regulated by ARF6, however a separate report indicates the apparent Arf6 dependency of Nef-mediated MHC class I down-modulation is due to nonspecific perturbations in membrane traffic PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 6 (ARF6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Overexpression of an active form of Arf6 (Arf6/Q67L), which induces the formation of PI(4,5)P2-enriched endosomal structures, severely reduces HIV-1 Gag virus production by redirecting Gag to PI(4,5)P2-enriched vesicles PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp564M0264

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein N-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thioesterase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of epithelial cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    liver development IEA
    Inferred from Electronic Annotation
    more info
     
    movement of cell or subcellular component TAS
    Traceable Author Statement
    more info
    PubMed 
    myeloid cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of establishment of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to endosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rac protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ADP-ribosylation factor 6
    NP_001654.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001663.3NP_001654.1  ADP-ribosylation factor 6

      See identical proteins and their annotated locations for NP_001654.1

      Status: REVIEWED

      Source sequence(s)
      AL121163, BC008918, BC030291, BM838197, DA217686
      Consensus CDS
      CCDS9695.1
      UniProtKB/Swiss-Prot
      P62330
      Related
      ENSP00000298316, OTTHUMP00000178980, ENST00000298316, OTTHUMT00000276883
      Conserved Domains (2) summary
      cd04149
      Location:5172
      Arf6; ADP ribosylation factor 6 (Arf6)
      TIGR00231
      Location:13157
      small_GTP; small GTP-binding protein domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

      Range
      49893018..49897054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      50297978..50302011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)