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IL21 interleukin 21 [ Bos taurus (cattle) ]

Gene ID: 378475, updated on 6-May-2015
Gene symbol
IL21
Gene description
interleukin 21
See related
BGD:BT11716; Ensembl:ENSBTAG00000012368
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Annotation category: partial on reference assembly
Orthologs
See IL21 in MapViewer
Location:
chromosome: 17
Exon count:
5
Annotation release Status Assembly Chr Location
104 current Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 17 AC_000174.1 (35462669..35469800)

Chromosome 17 - AC_000174.1Genomic Context describing neighboring genes Neighboring gene Bardet-Biedl syndrome 12 Neighboring gene centrin 4 Neighboring gene uncharacterized LOC104974609 Neighboring gene interleukin 2

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-2 receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell maturation IEA
Inferred from Electronic Annotation
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-17 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat1 protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
interleukin-21
Names
interleukin-21
IL-21

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198832.1NP_942129.1  interleukin-21 precursor

    See identical proteins and their annotated locations for NP_942129.1

    Status: PROVISIONAL

    Source sequence(s)
    AB073021
    UniProtKB/Swiss-Prot
    Q76LU5
    Related
    ENSBTAP00000016413, ENSBTAT00000016413
    Conserved Domains (1) summary
    pfam02372
    Location:41147
    IL15; Interleukin 15

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1.1 Primary Assembly

Genomic

  1. AC_000174.1 Reference Bos_taurus_UMD_3.1.1 Primary Assembly

    Range
    35462669..35469800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Btau_4.6.1

Genomic

  1. NC_007315.5 Alternate Btau_4.6.1

    Range
    36607735..36614866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)