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CDK5 cyclin-dependent kinase 5 [ Homo sapiens (human) ]

Gene ID: 1020, updated on 17-Jan-2015
Official Symbol
CDK5provided by HGNC
Official Full Name
cyclin-dependent kinase 5provided by HGNC
Primary source
HGNC:HGNC:1774
See related
Ensembl:ENSG00000164885; HPRD:00449; MIM:123831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSSALRE
Orthologs
See CDK5 in MapViewer
Location:
7q36
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (151053812..151057965, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150750899..150755052, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 8 Neighboring gene acid sensing (proton gated) ion channel 3 Neighboring gene solute carrier family 4 (anion exchanger), member 2 Neighboring gene Fas-activated serine/threonine kinase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with CDK5 PubMed
Tat tat HIV-1 Tat increases levels of phosphorylated Cdk5 in human neuronal cells PubMed
tat Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING PubMed
tat Neural cells expressing Tat reduces the phosphorylation level of neurofilaments by p35/Cdk5 PubMed
tat HIV-1 Tat downregulates the expression of p35, a neuron-specific activator of cdk5, and also binds to Puralpha, which associates with cdk5, leading to deregulation of neuronal differentiation and survival PubMed

Go to the HIV-1, Human Interaction Database

  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
    Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
    BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • CRMPs in Sema3A signaling, organism-specific biosystem (from REACTOME)
    CRMPs in Sema3A signaling, organism-specific biosystemCRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's under...
  • Cocaine addiction, organism-specific biosystem (from KEGG)
    Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Cocaine addiction, conserved biosystem (from KEGG)
    Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • DARPP-32 events, organism-specific biosystem (from REACTOME)
    DARPP-32 events, organism-specific biosystemDopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation D...
  • DNA damage response, organism-specific biosystem (from WikiPathways)
    DNA damage response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHA forward signaling, organism-specific biosystem
    EPHA forward signaling
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
    Glucocorticoid receptor regulatory network, organism-specific biosystem
    Glucocorticoid receptor regulatory network
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
  • Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem (from Pathway Interaction Database)
    Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem
    Lissencephaly gene (LIS1) in neuronal migration and development
  • Nicotine Activity on Dopaminergic Neurons, organism-specific biosystem (from WikiPathways)
    Nicotine Activity on Dopaminergic Neurons, organism-specific biosystemNicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body,...
  • Opioid Signalling, organism-specific biosystem (from REACTOME)
    Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
  • Reelin signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Reelin signaling pathway, organism-specific biosystem
    Reelin signaling pathway
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Trk receptor signaling mediated by the MAPK pathway, organism-specific biosystem (from Pathway Interaction Database)
    Trk receptor signaling mediated by the MAPK pathway, organism-specific biosystem
    Trk receptor signaling mediated by the MAPK pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ErbB-2 class receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ErbB-3 class receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
acetylcholine receptor activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
p53 binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Schwann cell development IEA
Inferred from Electronic Annotation
more info
 
axon extension TAS
Traceable Author Statement
more info
PubMed 
axon guidance TAS
Traceable Author Statement
more info
 
behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
calcium ion import IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
cerebellar cortex formation IEA
Inferred from Electronic Annotation
more info
 
corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryo development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
layer formation in cerebral cortex IEA
Inferred from Electronic Annotation
more info
 
motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron apoptotic process TAS
Traceable Author Statement
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
neuron migration TAS
Traceable Author Statement
more info
PubMed 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of actin cytoskeleton reorganization TAS
Traceable Author Statement
more info
PubMed 
positive regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein localization to synapse IEA
Inferred from Electronic Annotation
more info
 
receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 
receptor clustering IEA
Inferred from Electronic Annotation
more info
 
regulated secretory pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of excitatory postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of synaptic vesicle recycling NAS
Non-traceable Author Statement
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
serine phosphorylation of STAT3 protein IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
synapse assembly TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle endocytosis TAS
Traceable Author Statement
more info
PubMed 
synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
PubMed 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein kinase 5 holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular junction ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cyclin-dependent-like kinase 5
Names
cyclin-dependent-like kinase 5
TPKII catalytic subunit
protein kinase CDK5 splicing
cell division protein kinase 5
serine/threonine-protein kinase PSSALRE
tau protein kinase II catalytic subunit
NP_001157882.1
NP_004926.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164410.2NP_001157882.1  cyclin-dependent-like kinase 5 isoform 2

    See proteins identical to NP_001157882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), also known as CDK5-SV, omits an in-frame coding exon compared to variant 1 resulting in a shorter predicted protein (isoform 2). Expression of this transcript was described by Li et al. (2009; PubMed ID 19693690).
    Source sequence(s)
    AC010973, AK026533, CA429180, DB487008, DQ411039
    Consensus CDS
    CCDS55184.1
    UniProtKB/Swiss-Prot
    Q00535
    Conserved Domains (2) summary
    PLN00009
    Location:1256
    PLN00009; cyclin-dependent kinase A; Provisional
    cl21453
    Location:3254
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  2. NM_004935.3NP_004926.1  cyclin-dependent-like kinase 5 isoform 1

    See proteins identical to NP_004926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010973, AK026533, BC005115, BP309068, CA429180, DB487008
    Consensus CDS
    CCDS47748.1
    UniProtKB/TrEMBL
    A0A090N7W4
    UniProtKB/Swiss-Prot
    Q00535
    Related
    ENSP00000481070, ENST00000618146
    Conserved Domains (2) summary
    cd07839
    Location:3286
    STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5
    PLN00009
    Location:1288
    PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    151053812..151057965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    150759247..150763400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    144563235..144567388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)