wdr-5.1 WD repeat-containing protein wdr-5.1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: wdr-5.1
Gene description: WD repeat-containing protein wdr-5.1
Primary source: WormBase:WBGene00006474
Locus tag: CELE_C14B1.4
See related: AllianceGenome:WB:WBGene00006474
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; histone H3-K4 methylation; and transdifferentiation. Located in cytoplasm and nucleus. Part of MLL3/4 complex. Is expressed in several structures, including P3.p hermaphrodite; hermaphrodite gonad; hypodermis; neurons; and somatic gonad precursor. Orthologous to several human genes including WDR5 (WD repeat domain 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (3705285..3706784)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the transgenerational aspects of wdr-5 mutant longevity require the H3K9me2 methyltransferase MET-2 (MET-2).
Title: Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans.
WDR-5.1 associates with the fog-3 promoter and is required for TRA-1 to bind to fog-3 promoter.
Title: A role for WDR5 in TRA-1/Gli mediated transcriptional control of the sperm/oocyte switch in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C14B1.3 (e-PCR)
- UniSTS:321220

C14B1.4 (e-PCR)
- UniSTS:321221

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in transdifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transdifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MLL3/4 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Set1C/COMPASS complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WD repeat-containing protein wdr-5.1

NP_497749.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3705285..3706784

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065348.10 → NP_497749.1 WD repeat-containing protein wdr-5.1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497749.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17963

Conserved Domains (3) summary

COG2319
Location:76 → 372

WD40; WD40 repeat [General function prediction only]

cd00200
Location:79 → 373

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:90 → 127

7WD40; WD40 repeat [structural motif]