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    FN1 fibronectin 1 [ Homo sapiens (human) ]

    Gene ID: 2335, updated on 5-Jul-2015
    Official Symbol
    FN1provided by HGNC
    Official Full Name
    fibronectin 1provided by HGNC
    Primary source
    HGNC:HGNC:3778
    See related
    Ensembl:ENSG00000115414; HPRD:00626; MIM:135600; Vega:OTTHUMG00000133054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2
    Summary
    This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2q34
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (215360454..215436167, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216225177..216300890, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928103 Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 12 Neighboring gene uncharacterized LOC105373867 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC105373868 Neighboring gene uncharacterized LOC102724849

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Glomerulopathy with fibronectin deposits 2
    MedGen: C1866075 OMIM: 601894 GeneReviews: Not available
    Compare labs
    Plasma fibronectin deficiency
    MedGen: C2675436 OMIM: 614101 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
    NHGRI GWA Catalog
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces phosphorylation of fibronectin and enhances a physical association between fibronectin and Robo4 in human lymphatic endothelial cells PubMed
    env Fibronectin, which is present in submandibular saliva, binds to HIV-1 gp120/160 and enhances the interaction of C1q with gp120/160 PubMed
    env HIV-1 gp120 binds to fibronectin (FN) present on the surface of platelets; the specificity of this binding is confirmed by the inhibition obtained by pretreating platelets with anti-FN antibodies PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4 PubMed
    Envelope transmembrane glycoprotein gp41 env Fibronectin (FN) binds to HIV-1 glycoproteins, including gp41 and gp120; preincubation with antibodies against FN abolishes this binding PubMed
    Nef nef Exogenous HIV-1 Nef upregulates fibronectin (FN) expression in MT4 and H9 T-cell lines PubMed
    Tat tat HIV-1 Tat competes with fibronectin for binding to integrins PubMed
    tat Fibronectin modulates the effects of HIV-1 Tat on endothelial cells and murine Kaposi's sarcoma-like cells PubMed
    tat HIV-1 Tat upregulates fibronectin expression in salivary gland cell lines, thymic epithelial cells, and glioblastoma cells PubMed
    retropepsin gag-pol The cell-associated protein fibronectin (A-chain) is specifically cleaved in vitro by HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp686H0342, DKFZp686I1370, DKFZp686F10164, DKFZp686O13149

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    collagen binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    heparin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    calcium-independent cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-substrate junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    endodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    negative regulation of transforming growth factor-beta secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
     
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of substrate-dependent cell migration, cell attachment to substrate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to wounding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basal lamina IEA
    Inferred from Electronic Annotation
    more info
     
    blood microparticle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibrinogen complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    fibronectin
    Names
    cold-insoluble globulin
    migration-stimulating factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012196.1 RefSeqGene

      Range
      5001..80615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306129.1NP_001293058.1  fibronectin isoform 8 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains a segment with an alternate splice structure in the 3' coding region, compared to variant 1. Isoform 8 encoded by this variant is shorter than isoform 1.
      Source sequence(s)
      AI033037, AJ535086, BC143754, BX537590, BX640803, BX640875, CA422234, CR749316, CR749317, DA851446
      Consensus CDS
      CCDS77526.1
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:21662238
      fn3; Fibronectin type III domain
    2. NM_001306130.1NP_001293059.1  fibronectin isoform 9 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. Isoform 9 encoded by this variant has a distinct internal amino acid and is shorter than isoform 1.
      Source sequence(s)
      AI033037, AJ535086, BC143754, BX640803, BX640875, CA422234, CR749316, CR749317, DA851446
      Consensus CDS
      CCDS77525.1
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20012059
      fn3; Fibronectin type III domain
    3. NM_001306131.1NP_001293060.1  fibronectin isoform 10 preproprotein

      See identical proteins and their annotated locations for NP_001293060.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks two alternate in-frame exons in the central and 3' coding regions, and contains a segment with an alternate splice structure in the 3' coding region, compared to variant 1. Isoform 10 encoded by this variant has a distinct internal amino acid and is shorter than isoform 1.
      Source sequence(s)
      AI033037, AJ535086, BQ005645, BX640803, BX640875, BX640999, CR749281, CR749317, DA851446, U60068
      Consensus CDS
      CCDS77523.1
    4. NM_001306132.1NP_001293061.1  fibronectin isoform 11 preproprotein

      See identical proteins and their annotated locations for NP_001293061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks two alternate in-frame exons in the central and 3' coding regions, and contains a segment with an alternate splice structure in the 3' coding region, compared to variant 1. Isoform 11 encoded by this variant has a distinct internal amino acid and is shorter than isoform 1.
      Source sequence(s)
      AI033037, AJ535086, BC143754, BX640803, BX640875, CA422234, CR749317, DA851446, U60068
      Consensus CDS
      CCDS77522.1
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:19602032
      fn3; Fibronectin type III domain
    5. NM_002026.2NP_002017.1  fibronectin isoform 3 preproprotein

      See identical proteins and their annotated locations for NP_002017.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon and an internal segment in the coding region, as compared to variant 1. Isoform 3 encoded by this variant thus lacks two internal segments, as compared to isoform 1.
      Source sequence(s)
      AI033037, AJ535086, BQ005645, BX640638, BX640731, BX640802, X02761
      Consensus CDS
      CCDS2399.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q6MZF4
      UniProtKB/TrEMBL
      Q6N084
      Related
      ENSP00000338200, OTTHUMP00000164055, ENST00000336916, OTTHUMT00000256669
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20752147
      fn3; Fibronectin type III domain
    6. NM_054034.2NP_473375.2  fibronectin isoform 7 preproprotein

      See identical proteins and their annotated locations for NP_473375.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks multiple 3' exons and has an alternate 3' end, as compared to variant 1. Isoform 7 encoded by this variant is much shorter and has a distinct C-terminus, as compared isoform 1.
      Source sequence(s)
      AJ276395, AJ535086, BX640608
      Consensus CDS
      CCDS46512.1
      UniProtKB/Swiss-Prot
      P02751
      Related
      ENSP00000398907, OTTHUMP00000206767, ENST00000426059, OTTHUMT00000337235
      Conserved Domains (2) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    7. NM_212474.1NP_997639.1  fibronectin isoform 6 preproprotein

      See identical proteins and their annotated locations for NP_997639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two in-frame exons and an in-frame segment in the coding region, as compared to variant 1. Isoform 6 encoded by this variant thus lacks three internal segments, as compared to isoform 1.
      Source sequence(s)
      AI033037, AJ535086, AL832202, BQ005645, U60068, X02761
      Consensus CDS
      CCDS2400.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q9UQS6
      Related
      ENSP00000350534, OTTHUMP00000164056, ENST00000357867, OTTHUMT00000256670
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:19101968
      fn3; Fibronectin type III domain
    8. NM_212476.1NP_997641.1  fibronectin isoform 5 preproprotein

      See identical proteins and their annotated locations for NP_997641.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, as compared to variant 1. Isoform 5 encoded by this variant thus lacks two internal segments, as compared to isoform 1.
      Source sequence(s)
      AI033037, AJ535086, BQ005645, BX640608, U60068, X02761
      Consensus CDS
      CCDS42813.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q9UQS6
      Related
      ENSP00000348285, OTTHUMP00000206766, ENST00000356005, OTTHUMT00000337234
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20302088
      fn3; Fibronectin type III domain
    9. NM_212478.1NP_997643.1  fibronectin isoform 4 preproprotein

      See identical proteins and their annotated locations for NP_997643.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon and two in-frame segments in the coding region, as compared to variant 1. Isoform 4 encoded by this variant thus lacks three internal segments, as compared to isoform 1.
      Source sequence(s)
      AI033037, AJ535086, BQ005645, BX640802, U60068, X02761
      Consensus CDS
      CCDS46510.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q6MZF4
      UniProtKB/TrEMBL
      Q9UQS6
      Related
      ENSP00000410422, OTTHUMP00000206762, ENST00000446046, OTTHUMT00000337229
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20502122
      fn3; Fibronectin type III domain
    10. NM_212482.1NP_997647.1  fibronectin isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_997647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI033037, AJ535086, BQ005645, BX640803, BX640875, BX640999, U60068
      Consensus CDS
      CCDS42814.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q6MZM7
      UniProtKB/TrEMBL
      Q9UQS6
      Related
      ENSP00000346839, OTTHUMP00000164053, ENST00000354785, OTTHUMT00000256667
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:22112269
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

      Range
      215360454..215436167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246417.1XP_005246474.1  

      Related
      ENSP00000394423, OTTHUMP00000206760, ENST00000421182, OTTHUMT00000337226
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:19602032
      fn3; Fibronectin type III domain
    2. XM_005246412.1XP_005246469.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20052063
      fn3; Fibronectin type III domain
    3. XM_005246415.1XP_005246472.1  

      Related
      ENSP00000415018, OTTHUMP00000206763, ENST00000443816, OTTHUMT00000337230
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:19852057
      fn3; Fibronectin type III domain
    4. XM_005246414.1XP_005246471.1  

      Conserved Domains (3) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    5. XM_005246409.1XP_005246466.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20952153
      fn3; Fibronectin type III domain
    6. XM_005246406.1XP_005246463.1  

      See identical proteins and their annotated locations for XP_005246463.1

      UniProtKB/Swiss-Prot
      P02751
      Related
      ENSP00000352696, ENST00000359671
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:21202178
      fn3; Fibronectin type III domain
    7. XM_005246413.1XP_005246470.1  

      Related
      ENSP00000399538, OTTHUMP00000206765, ENST00000432072, OTTHUMT00000337233
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20012059
      fn3; Fibronectin type III domain
    8. XM_005246405.1XP_005246462.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:21212179
      fn3; Fibronectin type III domain
    9. XM_005246402.1XP_005246459.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:21412213
      fn3; Fibronectin type III domain
    10. XM_005246400.1XP_005246457.1  

      Related
      ENSP00000323534, OTTHUMP00000164054, ENST00000323926, OTTHUMT00000256668
      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:21662238
      fn3; Fibronectin type III domain
    11. XM_005246416.1XP_005246473.1  

      Conserved Domains (3) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    12. XM_005246404.1XP_005246461.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:21202178
      fn3; Fibronectin type III domain
    13. XM_005246411.1XP_005246468.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20012059
      fn3; Fibronectin type III domain
    14. XM_005246410.1XP_005246467.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20512123
      fn3; Fibronectin type III domain
    15. XM_005246408.1XP_005246465.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20762148
      fn3; Fibronectin type III domain
    16. XM_005246403.1XP_005246460.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:21212179
      fn3; Fibronectin type III domain
    17. XM_005246407.1XP_005246464.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:20912149
      fn3; Fibronectin type III domain
    18. XM_005246401.1XP_005246458.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:21412213
      fn3; Fibronectin type III domain
    19. XM_005246398.1XP_005246455.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:21862244
      fn3; Fibronectin type III domain
    20. XM_005246399.1XP_005246456.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:21662238
      fn3; Fibronectin type III domain
    21. XM_005246397.1XP_005246454.1  

      Conserved Domains (4) summary
      cd00061
      Location:559602
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:354401
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:22112269
      fn3; Fibronectin type III domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      216231077..216306650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212475.1: Suppressed sequence

      Description
      NM_212475.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.