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Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [ Mus musculus (house mouse) ]

Gene ID: 21943, updated on 19-Sep-2014
Official Symbol
Tnfsf11provided by MGI
Official Full Name
tumor necrosis factor (ligand) superfamily, member 11provided by MGI
Primary source
MGI:MGI:1100089
See related
Ensembl:ENSMUSG00000022015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ODF; OPG; OPGL; RANKL; Ly109l; Trance
See Tnfsf11 in Epigenomics, MapViewer
Location:
14 D3; 14 41.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 14 NC_000080.6 (78277446..78308043, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102632570 Neighboring gene microRNA 1971 Neighboring gene uncharacterized LOC102632639 Neighboring gene lactate dehydrogenase A pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Osteoblast, organism-specific biosystem (from WikiPathways)
    Osteoblast, organism-specific biosystem
    Osteoblast
  • Osteoclast, organism-specific biosystem (from WikiPathways)
    Osteoclast, organism-specific biosystem
    Osteoclast
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
    Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Prolactin signaling pathway, conserved biosystem (from KEGG)
    Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor receptor superfamily binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
TNFSF11-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
bone resorption IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
lymph node development TAS
Traceable Author Statement
more info
PubMed 
mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
osteoclast proliferation IDA
Inferred from Direct Assay
more info
 
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
positive regulation of corticotropin-releasing hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fever generation by positive regulation of prostaglandin secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoclast development IDA
Inferred from Direct Assay
more info
 
positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tumor necrosis factor ligand superfamily member 11
Names
tumor necrosis factor ligand superfamily member 11
OPG ligand
osteoprotegerin ligand
osteoclast differentiation factor
receptor activator of NF-kappaB ligand
TNF-related activation-induced cytokine
receptor activator of nuclear factor kappa B ligand
receptor activator of nuclear factor kappa-B ligand
tumor necrosis factor-related activation-induced cytokine

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011613.3NP_035743.2  tumor necrosis factor ligand superfamily member 11

    See proteins identical to NP_035743.2

    Status: VALIDATED

    Source sequence(s)
    AF019048, AK159498
    Consensus CDS
    CCDS27294.1
    UniProtKB/Swiss-Prot
    O35235
    Related
    ENSMUSP00000022592, ENSMUST00000022592
    Conserved Domains (1) summary
    cd00184
    Location:163310
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000080.6 

    Range
    78277446..78308043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000036.1 

    Range
    75790488..75821164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)