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ADIPOR1 adiponectin receptor 1 [ Homo sapiens (human) ]

Gene ID: 51094, updated on 7-Dec-2014
Official Symbol
ADIPOR1provided by HGNC
Official Full Name
adiponectin receptor 1provided by HGNC
Primary source
HGNC:HGNC:24040
Locus tag
CGI-45
See related
Ensembl:ENSG00000159346; HPRD:06402; MIM:607945; Vega:OTTHUMG00000041391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A
Summary
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
See ADIPOR1 in Epigenomics, MapViewer
Location:
1q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (202940829..202958572, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202909960..202927700, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAB interacting factor Neighboring gene kelch-like family member 12 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 59 Neighboring gene cytochrome b5 reductase 1 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein LOC641515 homolog Neighboring gene ribosomal protein S20 pseudogene 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AMPK signaling, organism-specific biosystem (from WikiPathways)
    AMPK signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ25385, FLJ42464

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adiponectin binding IEA
Inferred from Electronic Annotation
more info
 
hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
adiponectin-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
fatty acid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
leptin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JAK-STAT cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
adiponectin receptor protein 1
Names
adiponectin receptor protein 1
progestin and adipoQ receptor family member I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290553.1NP_001277482.1  adiponectin receptor protein 1

    See proteins identical to NP_001277482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as R1T2) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AI251444, BC010743, DA523648
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  2. NM_001290557.1NP_001277486.1  adiponectin receptor protein 1

    See proteins identical to NP_001277486.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as R1T3) has an additional internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC096632, AI251444, BC010743, BI597715
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  3. NM_001290629.1NP_001277558.1  adiponectin receptor protein 1

    See proteins identical to NP_001277558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as R1T4) has an alternate 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AI251444, BC010743, BI597715, BX461217
    UniProtKB/Swiss-Prot
    Q96A54
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  4. NM_015999.5NP_057083.2  adiponectin receptor protein 1

    See proteins identical to NP_057083.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as R1T1) is a predominant transcript. All variants encode the same protein.
    Source sequence(s)
    AC096632, AI251444, BC010743
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Related
    ENSP00000341785, OTTHUMP00000038805, ENST00000340990, OTTHUMT00000099160
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    202940829..202958572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711360.1XP_006711423.1  

    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  2. XM_006711361.1XP_006711424.1  

    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    204332195..204349939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    174075616..174093389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_046083.1: Suppressed sequence

    Description
    NR_046083.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.