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    EMP65 Emp65p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856883, updated on 13-Apr-2024

    Summary

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    Gene symbol
    EMP65
    Gene description
    Emp65p
    Primary source
    SGD:S000000942
    Locus tag
    YER140W
    See related
    AllianceGenome:SGD:S000000942
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein folding in endoplasmic reticulum. Is integral component of endoplasmic reticulum membrane. Orthologous to human TAPT1 (transmembrane anterior posterior transformation 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EMP65 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (451565..453235)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II subunit B1 CTD phosphatase RTR1 Neighboring gene Cox15p Neighboring gene DNA-3-methyladenine glycosylase II

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation. Zhang S, et al. Cell, 2017 Oct 5. PMID 28919078
    2. Cdc1 removes the ethanolamine phosphate of the first mannose of GPI anchors and thereby facilitates the integration of GPI proteins into the yeast cell wall. Vazquez HM, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165136, Free PMC Article
    3. Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1. Friederichs JM, et al. G3 (Bethesda), 2012 Dec. PMID 23275891, Free PMC Article
    4. A Genetic Screen To Identify Genes Influencing the Secondary Redox Couple NADPH/NADP(+) in the Yeast Saccharomyces cerevisiae. Yadav S, et al. G3 (Bethesda), 2020 Jan 7. PMID 31757928, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding in endoplasmic reticulum HGI PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Emp65p
    NP_011067.3
    • Integral membrane protein of the ER; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS3; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      451565..453235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179030.3 → NP_011067.3  TPA: Emp65p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011067.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM47, P40085
      UniProtKB/TrEMBL
      A0A6A5PYK3, A6ZR97, B3LRQ3, C7GQ56, C8Z7G0, G2WD27, N1PA59
      Conserved Domains (1) summary
      pfam05346
      Location:143 → 455
      DUF747; Eukaryotic membrane protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40085.1

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