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IL18 interleukin 18 [ Homo sapiens (human) ]

Gene ID: 3606, updated on 6-Jul-2014
Official Symbol
IL18provided by HGNC
Official Full Name
interleukin 18provided by HGNC
Primary source
HGNC:5986
See related
Ensembl:ENSG00000150782; HPRD:02976; MIM:600953; Vega:OTTHUMG00000167006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGIF; IL-18; IL-1g; IL1F4
Summary
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
See IL18 in Epigenomics, MapViewer
Location:
11q22.2-q22.3
Exon count :
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (112143251..112164117, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (112013974..112034840, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 57 Neighboring gene translocase of inner mitochondrial membrane 8 homolog B (yeast) Neighboring gene succinate dehydrogenase complex, subunit D, integral membrane protein Neighboring gene testis expressed 12 Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 4 Neighboring gene beta-carotene oxygenase 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
NHGRI GWA Catalog
Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels.
NHGRI GWA Catalog
Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
NHGRI GWA Catalog
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    IL23-mediated signaling events, organism-specific biosystem
    IL23-mediated signaling events
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    IL27-mediated signaling events, organism-specific biosystem
    IL27-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 
T-helper 1 type immune response IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 
chemokine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
granulocyte macrophage colony-stimulating factor biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IDA
Inferred from Direct Assay
more info
 
interferon-gamma biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
interleukin-13 biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
interleukin-2 biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 
natural killer cell activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB import into nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NK T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of granulocyte macrophage colony-stimulating factor production IDA
Inferred from Direct Assay
more info
 
positive regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
positive regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of natural killer cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tissue remodeling IC
Inferred by Curator
more info
PubMed 
regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
sleep ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
type 2 immune response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
Preferred Names
interleukin-18
Names
interleukin-18
IL-1 gamma
iboctadekin
interleukin-1 gamma
IFN-gamma-inducing factor
interleukin 18 (interferon-gamma-inducing factor)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028143.1 

    Range
    5001..25867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243211.1NP_001230140.1  interleukin-18 isoform 2 proprotein

    See proteins identical to NP_001230140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing a 4 aa peptide compared to isoform 1.
    Source sequence(s)
    AY266351, BC007461, BU633686
    Consensus CDS
    CCDS58180.1
    UniProtKB/Swiss-Prot
    Q14116
    Related
    ENSP00000434561, OTTHUMP00000234750, ENST00000524595, OTTHUMT00000392410
    Conserved Domains (1) summary
    pfam00340
    Location:68181
    Blast Score: 311
    IL1; Interleukin-1 / 18
  2. NM_001562.3NP_001553.1  interleukin-18 isoform 1 proprotein

    See proteins identical to NP_001553.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AY266351, BC007461, BU633686, D49950
    Consensus CDS
    CCDS44731.1
    UniProtKB/Swiss-Prot
    Q14116
    Related
    ENSP00000280357, OTTHUMP00000234749, ENST00000280357, OTTHUMT00000392409
    Conserved Domains (1) summary
    pfam00340
    Location:72185
    Blast Score: 311
    IL1; Interleukin-1 / 18

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    112143251..112164117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    107938095..107959011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    111897441..111918303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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