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    PPP1R8 protein phosphatase 1 regulatory subunit 8 [ Bos taurus (cattle) ]

    Gene ID: 282319, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PPP1R8provided by VGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 8provided by VGNC
    Primary source
    VGNC:VGNC:33249
    See related
    BGD:BT11869; Ensembl:ENSBTAG00000003866
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (125527083..125545119, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene replication protein A2 Neighboring gene thymocyte selection associated family member 2 Neighboring gene mitochondrial carrier homolog 1-like Neighboring gene small Cajal body-specific RNA 1 Neighboring gene syntaxin 12 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene family with sequence similarity 76 member A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. Beullens M, et al. J Biol Chem, 1999 May 14. PMID 10318819
    2. NIPP-1, a nuclear inhibitory subunit of protein phosphatase-1, has RNA-binding properties. Jagiello I, et al. J Biol Chem, 1997 Aug 29. PMID 9268347
    3. Properties and phosphorylation sites of baculovirus-expressed nuclear inhibitor of protein phosphatase-1 (NIPP-1). Vulsteke V, et al. J Biol Chem, 1997 Dec 26. PMID 9407077
    4. Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly. van den Boom J, et al. Nat Struct Mol Biol, 2021 Dec. PMID 34824462
    5. Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing. Van Eynde A, et al. J Biol Chem, 1995 Nov 24. PMID 7499293

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear inhibitor of protein phosphatase 1
    Names
    NIPP-1
    protein phosphatase 1, regulatory inhibitor subunit 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174582.2 → NP_777007.1  nuclear inhibitor of protein phosphatase 1

      See identical proteins and their annotated locations for NP_777007.1

      Status: PROVISIONAL

      Source sequence(s)
      Z50748
      UniProtKB/Swiss-Prot
      Q28147
      Related
      ENSBTAP00000092560.1, ENSBTAT00000105378.1
      Conserved Domains (3) summary
      COG1716
      Location:41 → 151
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:27 → 119
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam11945
      Location:98 → 212
      WASH_WAHD; WAHD domain of WASH complex

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      125527083..125545119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28147.1 GenPept UniProtKB/Swiss-Prot:Q28147

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