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    CHN1 chimerin 1 [ Macaca fascicularis (crab-eating macaque) ]

    Gene ID: 102119357, updated on 3-Apr-2024

    Summary

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    Gene symbol
    CHN1
    Gene description
    chimerin 1
    See related
    Ensembl:ENSMFAG00000002404
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca fascicularis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    102 current MFA1912RKSv2 (GCF_012559485.2) 12 NC_052266.1 (59612180..59811120, complement)
    101 previous assembly Macaca_fascicularis_5.0 (GCF_000364345.1) 12 NC_022283.1 (63743330..63943342, complement)

    Chromosome 12 - NC_052266.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene WAS/WASL interacting protein family member 1 Neighboring gene cholinergic receptor nicotinic alpha 1 subunit Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rate of evolution in brain-expressed genes in humans and other primates. Wang HY, et al. PLoS Biol, 2007 Feb. PMID 17194215, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ephrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-chimaerin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca fascicularis Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference MFA1912RKSv2 Primary Assembly

    Genomic

    1. NC_052266.1 Reference MFA1912RKSv2 Primary Assembly

      Range
      59612180..59811120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045367286.1 → XP_045223221.1  N-chimaerin isoform X5

      Conserved Domains (3) summary
      cd10352
      Location:42 → 128
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd20856
      Location:201 → 257
      C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins
      cl02570
      Location:266 → 413
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    2. XM_005573530.3 → XP_005573587.1  N-chimaerin isoform X1

      See identical proteins and their annotated locations for XP_005573587.1

      UniProtKB/TrEMBL
      A0A2K5TZQ2, G7PKV4
      Related
      ENSMFAP00000005562.1
      Conserved Domains (3) summary
      cd10352
      Location:42 → 128
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:266 → 459
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20856
      Location:201 → 257
      C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

    3. XM_045367284.1 → XP_045223219.1  N-chimaerin isoform X3

    4. XM_045367285.1 → XP_045223220.1  N-chimaerin isoform X4

      Conserved Domains (3) summary
      cd10352
      Location:16 → 102
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:240 → 433
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20856
      Location:175 → 231
      C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

    5. XM_045367283.1 → XP_045223218.1  N-chimaerin isoform X2

      Conserved Domains (3) summary
      cd10352
      Location:29 → 115
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:253 → 446
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20856
      Location:188 → 244
      C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

    6. XM_015432381.2 → XP_015287867.1  N-chimaerin isoform X6

      UniProtKB/TrEMBL
      A0A2K5TZW7, I7G3U4
      Related
      ENSMFAP00000005519.1
      Conserved Domains (2) summary
      cd04372
      Location:86 → 279
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20856
      Location:21 → 77
      C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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