par-6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: par-6provided by FlyBase
Primary source: FLYBASE:FBgn0026192
Locus tag: Dmel_CG5884
See related: AllianceGenome:FB:FBgn0026192
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5884; Dm-Par-6; Dm-Par6; Dmel\CG5884; dmPar-6; DmPar-6; DmPAR-6; Dmpar6; DmPar6; dPar-6; dPAR-6; DPar-6; DPar6; par; Par; Par-6; PAR-6; par6; Par6; PAR6
Summary: Predicted to enable protein kinase C binding activity. Involved in several processes, including border follicle cell migration; nervous system development; and positive regulation of plasma membrane bounded cell projection assembly. Located in several cellular components, including apical cortex; apical plasma membrane; and muscle cell postsynaptic specialization. Is expressed in several structures, including embryonic hindgut; epithelium; muscle cell; neuroblasts; and neurons. Orthologous to several human genes including PARD6B (par-6 family cell polarity regulator beta) and PARD6G (par-6 family cell polarity regulator gamma). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 16C1-16C1; 1-58 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (17703352..17707096)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17597385..17601129)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity.
Title: A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity.
Data show a PDZ domain-binding motif in Par6 that was essential for its interaction with Par3 in vitro and for Par3-mediated membrane localization of Par6 in cultured cells.
Title: Structural basis for the interaction between the cell polarity proteins Par3 and Par6.
Par-6 binds to Crumbs through a carboxyl-terminal peptide contributing to the crystal structure of the PDZ-peptide complex.
Title: Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42.
Slmb has a role in control of oocyte and epithelial polarity by antagonizing the aPKC/Par-6 complex
Title: Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity.
the Par-6-aPKC complex, is recruited to the apicomedial domain by actomyosin networks during dorsal closure of the embryo.
Title: Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constriction.
in complex with Par-3 and integrins, direct asymmetric cell division in adult intestinal stem cells
Title: The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells.
there is a mutual dependence between Par proteins and Cdc42 for their localization, regulation of the actin cytoskeleton and, consequently, for the establishment of oocyte polarity
Title: A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization.
Par-6 allosterically activates aPKC to allow for high spatial and temporal control of substrate phosphorylation and polarization.
Title: Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement.
a unique dipeptide switch in the Par-6 PDZ domain transmits a signal for allosteric activation to the ligand-binding pocket
Title: A conformational switch in the CRIB-PDZ module of Par-6.
Results identify the Cdc42/Par6/atypical protein kinase C (aPKC) Par polarity complex as uniquely and specifically regulating apoptosis-induced compensatory proliferation in Drosophila epithelia.
Title: The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apical protein localization	NAS Non-traceable Author Statement more info	PubMed
involved_in asymmetric neuroblast division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of neuroblast polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	NAS Non-traceable Author Statement more info	PubMed
involved_in establishment or maintenance of neuroblast polarity	NAS Non-traceable Author Statement more info	PubMed
involved_in establishment or maintenance of polarity of embryonic epithelium	NAS Non-traceable Author Statement more info	PubMed
involved_in morphogenesis of a polarized epithelium	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zonula adherens assembly	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical cortex	NAS Non-traceable Author Statement more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in cell cortex	TAS Traceable Author Statement more info	PubMed
located_in muscle cell postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
part_of subapical complex	TAS Traceable Author Statement more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: par-6

Names: CG5884-PA; CG5884-PB; Par-6; Par6; par-6-PA; par-6-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

17703352..17707096

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_133010.5 → NP_573238.1 par-6, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_573238.1

Status: REVIEWED

UniProtKB/TrEMBL

O97111

Related

FBpp0074229

Conserved Domains (2) summary

cd06403
Location:20 → 101

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:159 → 250

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_167575.2 → NP_728094.1 par-6, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728094.1

Status: REVIEWED

UniProtKB/TrEMBL

O97111

Related

FBpp0074230

Conserved Domains (2) summary

cd06403
Location:20 → 101

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:159 → 250

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...