drk downstream of receptor kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: drkprovided by FlyBase
Official Full Name: downstream of receptor kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0004638
Locus tag: Dmel_CG6033
See related: AllianceGenome:FB:FBgn0004638
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 24/1; CG6033; crkl; Dmel\CG6033; Drk; DRK; Drk/Grb2; E(sev)2B; Grb-2; Grb/drk; Grb2; GRB2; Grb2/drk; l(2)10626; l(2)k13809; P1112; Su(sev)R1
Summary: Enables several functions, including phosphotyrosine residue binding activity; protein C-terminus binding activity; and signaling receptor binding activity. Involved in several processes, including learning or memory; open tracheal system development; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in plasma membrane and presynapse. Part of protein-containing complex. Is expressed in several structures, including adult brain; anterior endoderm; extended germ band embryo; imaginal disc; and synaptic neuropil block. Used to study autosomal recessive nonsyndromic deafness 114. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 50A13-50A13; 2-68 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13495222..13502841, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9382727..9390346, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions of the N- and C-Terminal SH3 Domains of Drosophila Drk with the Proline-Rich Peptides from Sos and Dos.
Title: Interactions of the N- and C-Terminal SH3 Domains of Drosophila Drk with the Proline-Rich Peptides from Sos and Dos.
Disordered proteins mitigate the temperature dependence of site-specific binding free energies.
Title: Disordered proteins mitigate the temperature dependence of site-specific binding free energies.
identifies DRK/DOS/SOS as the upstream Rac GEF complex required for glial responses to axonal injury, and demonstrates a critical requirement for multiple GEFs in efficient glial activation after injury and internalization/degradation of axonal debris
Title: DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris.
Drk plays a negative role in EGFR signaling by enhancing receptor endocytosis through cooperating with the RING domain of D-Cbl.
Title: D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis.
size distribution of molecules within an unfolded state of the N-terminal SH3 domain of drk (drkN SH3) has been studied by small-angle X-ray scattering (SAXS) and pulsed-field-gradient NMR (PFG-NMR) methods
Title: Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques.
SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases.
Title: SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases.
Signalling from the pTyr (YB) Neu (ErbB-2) autophosphorylation site was affected by a haplosufficiency in drk (Grb-2), and in genes thought to function downstream of Grb-2: dab, sos, csw (Shp-2), and dos (Gab-1).
Title: Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model.
residue-specific pK(a) values for a thermodynamically unstable Src homology 3 domain, enabling the calculation of the pH dependence of stability based on simple analytical expressions
Title: Site-specific contributions to the pH dependence of protein stability.
Structural characterizations of the drkN SH3 domain unfolded state.
Title: Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure.
The drkN SH3 domain exists in equilibrium between folded (F(exch)) and unfolded (U(exch)) states
Title: Slow dynamics in folded and unfolded states of an SH3 domain.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0730 (e-PCR)
- UniSTS:5809

Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables epidermal growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphotyrosine residue binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sevenless binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R7 cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Ras protein signal transduction	IPI Inferred from Physical Interaction more info	PubMed
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IDA Inferred from Direct Assay more info	PubMed
involved_in sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sevenless signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in torso signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in torso signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in torso signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal outgrowth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: downstream of receptor kinase

Names: CG6033-PA; CG6033-PB; CG6033-PC; CG6033-PD; CG6033-PF; downstream of receptor kinases; downstream receptor kinase; drk-PA; drk-PB; drk-PC; drk-PD; drk-PF; enhancer of sevenless-2B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

13495222..13502841 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165998.2 → NP_725306.1 downstream of receptor kinase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725306.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZF9, Q08012, Q0E989, Q9V6Q5

Related

FBpp0086816

Conserved Domains (3) summary

cd09941
Location:56 → 149

SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins

cd11804
Location:2 → 53

SH3_GRB2_like_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins

cd11805
Location:156 → 208

SH3_GRB2_like_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins
NM_057510.4 → NP_476858.1 downstream of receptor kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476858.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZF9, Q08012, Q0E989, Q9V6Q5

Related

FBpp0086815

Conserved Domains (3) summary

cd09941
Location:56 → 149

SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins

cd11804
Location:2 → 53

SH3_GRB2_like_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins

cd11805
Location:156 → 208

SH3_GRB2_like_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins
NM_165996.2 → NP_725304.1 downstream of receptor kinase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725304.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZF9, Q08012, Q0E989, Q9V6Q5

Related

FBpp0086817

Conserved Domains (3) summary

cd09941
Location:56 → 149

SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins

cd11804
Location:2 → 53

SH3_GRB2_like_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins

cd11805
Location:156 → 208

SH3_GRB2_like_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins
NM_165994.2 → NP_725302.1 downstream of receptor kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725302.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZF9, Q08012, Q0E989, Q9V6Q5

Related

FBpp0086814

Conserved Domains (3) summary

cd09941
Location:56 → 149

SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins

cd11804
Location:2 → 53

SH3_GRB2_like_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins

cd11805
Location:156 → 208

SH3_GRB2_like_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins
NM_165995.2 → NP_725303.1 downstream of receptor kinase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725303.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZF9, Q08012, Q0E989, Q9V6Q5

Related

FBpp0086813

Conserved Domains (3) summary

cd09941
Location:56 → 149

SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins

cd11804
Location:2 → 53

SH3_GRB2_like_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins

cd11805
Location:156 → 208

SH3_GRB2_like_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins