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    Cyb5r3 cytochrome b5 reductase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25035, updated on 26-Jun-2015
    Official Symbol
    Cyb5r3provided by RGD
    Official Full Name
    cytochrome b5 reductase 3provided by RGD
    Primary source
    RGD:2502
    See related
    Ensembl:ENSRNOG00000009592
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dia1; Nadhcb5; RNNADHCB5
    Summary
    catalyzes the conversion of NADH, H+, and 2 ferricytochrome b(5) to NAD+ and 2 ferrocytochrome b(5) [RGD, Feb 2006]
    Orthologs
    See Cyb5r3 in MapViewer
    Location:
    7q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124024003..124041564, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (124006942..124024503, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene serine hydrolase-like 2 Neighboring gene ribosomal RNA processing 7 homolog A (S. cerevisiae) Neighboring gene polymerase (DNA-directed), delta interacting protein 3 Neighboring gene alpha 1,4-galactosyltransferase Neighboring gene similar to 60S ribosomal protein L36

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ADP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    AMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    FAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    NAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytochrome-b5 reductase activity, acting on NAD(P)H TAS
    Traceable Author Statement
    more info
    PubMed 
    flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    lipid particle IEA
    Inferred from Electronic Annotation
    more info
     
    lipid particle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    NADH-cytochrome b5 reductase 3
    Names
    NADH-cytochrome b5 reductase 3
    B5R
    Diaphorase (NADH) (cytochrome b-5 reductase)
    diaphorase 1
    diaphorase-1
    NP_620232.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138877.1NP_620232.1  NADH-cytochrome b5 reductase 3

      See identical proteins and their annotated locations for NP_620232.1

      Status: PROVISIONAL

      Source sequence(s)
      D00636
      UniProtKB/Swiss-Prot
      P20070
      Related
      ENSRNOP00000061381, ENSRNOT00000064700
      Conserved Domains (2) summary
      cd06183
      Location:45301
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      PTZ00319
      Location:16301
      PTZ00319; NADH-cytochrome B5 reductase; Provisional

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      124024003..124041564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242065.2XP_006242127.1  

      UniProtKB/Swiss-Prot
      P20070
      Conserved Domains (2) summary
      cd06183
      Location:51307
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      PTZ00319
      Location:22307
      PTZ00319; NADH-cytochrome B5 reductase; Provisional

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      110620903..110638468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)