TFDP1 transcription factor Dp-1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TFDP1provided by HGNC
Official Full Name: transcription factor Dp-1provided by HGNC
Primary source: HGNC:HGNC:11749
See related: Ensembl:ENSG00000198176 MIM:189902; AllianceGenome:HGNC:11749
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DP1; DILC; Dp-1; DRTF1
Summary: This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
Expression: Ubiquitous expression in bone marrow (RPKM 54.1), lymph node (RPKM 31.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q34

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (113584688..113641473)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (112843768..112900540)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (114239003..114295788)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.
Title: Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.
miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells.
Title: miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells.
It uncovered E2F1 and TFDP1 as transport substrates of KPNA2 being retained in the cytoplasm upon KPNA2 ablation, thereby resulting in reduced STMN1 expression.
Title: Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.
We observed a downregulation of TFDP1 in the endometrium cells of women with deep infiltrating endometriosis when compared to the controls
Title: Expression of the TFDP1 gene in the endometrium of women with deep infiltrating endometriosis.
DILC may mediate the crosstalk between the cascades of IL6/STAT3 and TNFalpha signaling, indicating that DILC may act as a prognostic biomarker of sepsis, and may serve as a potential therapeutic target for the treatment of sepsis.
Title: Long non‑coding RNA DILC is involved in sepsis by modulating the signaling pathway of the interleukin‑6/signal transducer and activator of transcription 3/Toll‑like receptor 4 axis.
COMMD9 participates in TFDP1/E2F1 activation and plays a critical role in non-small cell lung cancer.
Title: COMMD9 promotes TFDP1/E2F1 transcriptional activity via interaction with TFDP1 in non-small cell lung cancer.
Here, the authors show that an acidic region of DP1, whose function has remained elusive, binds to the plekstrin homology (PH) domain of the p62 subunit of TFIIH that contributes to transcriptional activation.
Title: The Interaction Mode of the Acidic Region of the Cell Cycle Transcription Factor DP1 with TFIIH.
role for E2F1 and TFDP1 in the transcriptional regulation of PITX1 in articular chondrocytes
Title: E2F1 and TFDP1 Regulate PITX1 Expression in Normal and Osteoarthritic Articular Chondrocytes.
According to our study results, the gene TFDP1 and the cell cycle pathway are strongly associated with high-grade glioblastoma multiforme (GBM); this result may provide new insights into the pathogenesis of GBM.
Title: Dysregulation of TFDP1 and of the cell cycle pathway in high-grade glioblastoma multiforme: a bioinformatic analysis.
Amplification of CUL4A, IRS2, and TFDP1 genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma.
Title: Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HSC0VG072 (e-PCR)
- UniSTS:20511

NoName (e-PCR)
- UniSTS:486219

D13S293 (e-PCR), detects polymorphism
- UniSTS:50565

SHGC-150653 (e-PCR)
- UniSTS:173488

RH1609 (e-PCR)
- UniSTS:35259

D13S1446 (e-PCR)
- UniSTS:66510

RH17637 (e-PCR)
- UniSTS:16341

RH70183 (e-PCR)
- UniSTS:50677

RH78077 (e-PCR)
- UniSTS:83967

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anoikis	IEA Inferred from Electronic Annotation more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in epidermis development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fat cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Rb-E2F complex	IPI Inferred from Physical Interaction more info	PubMed
part_of Rb-E2F complex	ISS Inferred from Sequence or Structural Similarity more info
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor Dp-1

Names: DRTF1-polypeptide 1; E2F dimerization partner 1; E2F-related transcription factor; down-regulated in liver cancer stem cells

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029909.1 RefSeqGene

Range

5066..61786

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_007111.5 → NP_009042.1 transcription factor Dp-1

See identical proteins and their annotated locations for NP_009042.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AL442125, BC011685

Consensus CDS

CCDS9538.1

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5

Related

ENSP00000364519.4, ENST00000375370.10

Conserved Domains (3) summary

cd14458
Location:198 → 244

DP_DD; coiled coil [structural motif]

pfam02319
Location:113 → 193

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:200 → 338

DP; Transcription factor DP

RNA

NR_026580.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK297114, AL442125, CD623680

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000013.11 Reference GRCh38.p14 Primary Assembly

Range

113584688..113641473

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017020717.2 → XP_016876206.1 transcription factor Dp-1 isoform X1
XM_005268327.2 → XP_005268384.1 transcription factor Dp-1 isoform X3

See identical proteins and their annotated locations for XP_005268384.1

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5

Conserved Domains (3) summary

cd14458
Location:198 → 244

DP_DD; coiled coil [structural motif]

pfam02319
Location:113 → 193

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:200 → 338

DP; Transcription factor DP
XM_017020718.2 → XP_016876207.1 transcription factor Dp-1 isoform X4

Conserved Domains (3) summary

cd14458
Location:198 → 244

DP_DD; coiled coil [structural motif]

pfam02319
Location:113 → 193

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:200 → 338

DP; Transcription factor DP
XM_017020719.3 → XP_016876208.1 transcription factor Dp-1 isoform X6

Conserved Domains (3) summary

cd14458
Location:198 → 244

DP_DD; coiled coil [structural motif]

pfam02319
Location:113 → 193

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:200 → 335

DP; Transcription factor DP
XM_047430562.1 → XP_047286518.1 transcription factor Dp-1 isoform X3

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5
XM_047430566.1 → XP_047286522.1 transcription factor Dp-1 isoform X3

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5
XM_047430569.1 → XP_047286525.1 transcription factor Dp-1 isoform X4
XM_047430554.1 → XP_047286510.1 transcription factor Dp-1 isoform X1
XM_047430561.1 → XP_047286517.1 transcription factor Dp-1 isoform X2
XM_047430570.1 → XP_047286526.1 transcription factor Dp-1 isoform X4
XM_047430575.1 → XP_047286531.1 transcription factor Dp-1 isoform X6
XM_047430564.1 → XP_047286520.1 transcription factor Dp-1 isoform X3

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5
XM_047430568.1 → XP_047286524.1 transcription factor Dp-1 isoform X4
XM_047430558.1 → XP_047286514.1 transcription factor Dp-1 isoform X1
XM_047430573.1 → XP_047286529.1 transcription factor Dp-1 isoform X6
XM_047430560.1 → XP_047286516.1 transcription factor Dp-1 isoform X1
XM_047430574.1 → XP_047286530.1 transcription factor Dp-1 isoform X6
XM_005268328.3 → XP_005268385.1 transcription factor Dp-1 isoform X4

See identical proteins and their annotated locations for XP_005268385.1

Conserved Domains (3) summary

cd14458
Location:198 → 244

DP_DD; coiled coil [structural motif]

pfam02319
Location:113 → 193

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:200 → 338

DP; Transcription factor DP
XM_047430557.1 → XP_047286513.1 transcription factor Dp-1 isoform X1
XM_047430559.1 → XP_047286515.1 transcription factor Dp-1 isoform X1
XM_047430563.1 → XP_047286519.1 transcription factor Dp-1 isoform X3

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5
XM_047430567.1 → XP_047286523.1 transcription factor Dp-1 isoform X4
XM_047430572.1 → XP_047286528.1 transcription factor Dp-1 isoform X6
XM_047430571.1 → XP_047286527.1 transcription factor Dp-1 isoform X5
XM_047430576.1 → XP_047286532.1 transcription factor Dp-1 isoform X7
XM_047430577.1 → XP_047286533.1 transcription factor Dp-1 isoform X8

Alternate T2T-CHM13v2.0

Genomic

NC_060937.1 Alternate T2T-CHM13v2.0

Range

112843768..112900540

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054374884.1 → XP_054230859.1 transcription factor Dp-1 isoform X1
XM_054374890.1 → XP_054230865.1 transcription factor Dp-1 isoform X3

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5
XM_054374896.1 → XP_054230871.1 transcription factor Dp-1 isoform X4
XM_054374902.1 → XP_054230877.1 transcription factor Dp-1 isoform X6
XM_054374892.1 → XP_054230867.1 transcription factor Dp-1 isoform X3

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5
XM_054374893.1 → XP_054230868.1 transcription factor Dp-1 isoform X3

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5
XM_054374882.1 → XP_054230857.1 transcription factor Dp-1 isoform X1
XM_054374888.1 → XP_054230863.1 transcription factor Dp-1 isoform X2
XM_054374899.1 → XP_054230874.1 transcription factor Dp-1 isoform X4
XM_054374905.1 → XP_054230880.1 transcription factor Dp-1 isoform X6
XM_054374898.1 → XP_054230873.1 transcription factor Dp-1 isoform X4
XM_054374891.1 → XP_054230866.1 transcription factor Dp-1 isoform X3

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5
XM_054374897.1 → XP_054230872.1 transcription factor Dp-1 isoform X4
XM_054374885.1 → XP_054230860.1 transcription factor Dp-1 isoform X1
XM_054374903.1 → XP_054230878.1 transcription factor Dp-1 isoform X6
XM_054374887.1 → XP_054230862.1 transcription factor Dp-1 isoform X1
XM_054374904.1 → XP_054230879.1 transcription factor Dp-1 isoform X6
XM_054374894.1 → XP_054230869.1 transcription factor Dp-1 isoform X4
XM_054374883.1 → XP_054230858.1 transcription factor Dp-1 isoform X1
XM_054374886.1 → XP_054230861.1 transcription factor Dp-1 isoform X1
XM_054374889.1 → XP_054230864.1 transcription factor Dp-1 isoform X3

UniProtKB/Swiss-Prot

B4DLQ9, Q14186, Q5JSB4, Q8IZL5
XM_054374895.1 → XP_054230870.1 transcription factor Dp-1 isoform X4
XM_054374901.1 → XP_054230876.1 transcription factor Dp-1 isoform X6
XM_054374900.1 → XP_054230875.1 transcription factor Dp-1 isoform X5
XM_054374906.1 → XP_054230881.1 transcription factor Dp-1 isoform X7
XM_054374907.1 → XP_054230882.1 transcription factor Dp-1 isoform X8