Sod3 superoxide dismutase 3, extracellular [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sod3provided by MGI
Official Full Name: superoxide dismutase 3, extracellularprovided by MGI
Primary source: MGI:MGI:103181
See related: Ensembl:ENSMUSG00000072941 AllianceGenome:MGI:103181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EC-SOD
Summary: Enables superoxide dismutase activity. Acts upstream of or within response to hypoxia. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and neural ectoderm. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 494.2), lung adult (RPKM 264.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C1; 5 27.92 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (52521146..52527080)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (52363804..52369738)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
Title: SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.
Title: Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.
Extracellular Superoxide Dismutase Prevents Skin Aging by Promoting Collagen Production through the Activation of AMPK and Nrf2/HO-1 Cascades.
Title: Extracellular Superoxide Dismutase Prevents Skin Aging by Promoting Collagen Production through the Activation of AMPK and Nrf2/HO-1 Cascades.
SOD3 deficiency induces liver fibrosis by promoting hepatic stellate cell activation and epithelial-mesenchymal transition.
Title: SOD3 deficiency induces liver fibrosis by promoting hepatic stellate cell activation and epithelial-mesenchymal transition.
Superoxide Dismutase 3 Controls the Activation and Differentiation of CD4(+)T Cells.
Title: Superoxide Dismutase 3 Controls the Activation and Differentiation of CD4(+)T Cells.
Superoxide Dismutase 3-Transduced Mesenchymal Stem Cells Preserve Epithelial Tight Junction Barrier in Murine Colitis and Attenuate Inflammatory Damage in Epithelial Organoids.
Title: Superoxide Dismutase 3-Transduced Mesenchymal Stem Cells Preserve Epithelial Tight Junction Barrier in Murine Colitis and Attenuate Inflammatory Damage in Epithelial Organoids.
Superoxide dismutase 3 is expressed in bone tissue and required for normal bone homeostasis and mineralization.
Title: Superoxide dismutase 3 is expressed in bone tissue and required for normal bone homeostasis and mineralization.
MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways.
Title: MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways.
Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.
Title: Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.
Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function.
Title: Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function.

Submit: New GeneRIF Correction See all GeneRIFs (89)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sod3 (e-PCR), detects polymorphism
- UniSTS:532569

Sod3 (e-PCR), detects polymorphism
- UniSTS:144479

Sod3 (e-PCR), detects polymorphism
- UniSTS:527562

AI314465 (e-PCR)
- UniSTS:179163

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to copper ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi lumen	TAS Traceable Author Statement more info
colocalizes_with collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: extracellular superoxide dismutase [Cu-Zn]

Names: extracellular superoxide dismutase

NP_035565.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.