Ltb4r1 leukotriene B4 receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ltb4r1provided by MGI
Official Full Name: leukotriene B4 receptor 1provided by MGI
Primary source: MGI:MGI:1309472
See related: Ensembl:ENSMUSG00000046908 AllianceGenome:MGI:1309472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BLT1; BLTR; Ltb4r; mBLTR; LTB4-R1
Summary: Enables leukotriene B4 receptor activity. Acts upstream of or within signal transduction. Predicted to be located in membrane raft. Predicted to be integral component of plasma membrane. Is expressed in brain and lateral ventricle. Orthologous to human LTB4R (leukotriene B4 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 10.3), small intestine adult (RPKM 8.5) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (56002154..56005951)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55765962..55768492)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
Title: n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity.
Title: Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity.
Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation.
Title: Expression of leukotriene B(4) receptor 1 defines functionally distinct DCs that control allergic skin inflammation.
Up-regulating microRNA-138-5p enhances the protective role of dexmedetomidine on myocardial ischemia-reperfusion injury mice via down-regulating Ltb4r1.
Title: Up-regulating microRNA-138-5p enhances the protective role of dexmedetomidine on myocardial ischemia-reperfusion injury mice via down-regulating Ltb4r1.
Acceleration of Trichinella spiralis worm expulsion by leukotriene B4 receptor binding inhibition.
Title: Acceleration of Trichinella spiralis worm expulsion by leukotriene B4 receptor binding inhibition.
Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
Title: Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
Constitutive activation of the NEAT1/miR-22-3p/Ltb4r1 signaling pathway in mice with myocardial injury following acute myocardial infarction.
Title: Constitutive activation of the NEAT1/miR-22-3p/Ltb4r1 signaling pathway in mice with myocardial injury following acute myocardial infarction.
Leukotriene B4 receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production.
Title: Leukotriene B(4) receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production.
The LTB4-BLT1 axis regulates actomyosin and beta2-integrin dynamics during neutrophil extravasation.
Title: The LTB4-BLT1 axis regulates actomyosin and β2-integrin dynamics during neutrophil extravasation.
Leukotriene B4 receptor 1 exacerbates inflammation following myocardial infarction.
Title: Leukotriene B(4) receptor 1 exacerbates inflammation following myocardial infarction.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables leukotriene B4 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene B4 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables leukotriene receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukotriene B4 receptor 1

Names: LTB4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411957.1 → NP_001398886.1 leukotriene B4 receptor 1

Status: VALIDATED

Source sequence(s)

AC098877

UniProtKB/Swiss-Prot

O88855

UniProtKB/TrEMBL

A7VJD3
NM_008519.3 → NP_032545.1 leukotriene B4 receptor 1

See identical proteins and their annotated locations for NP_032545.1

Status: VALIDATED

Source sequence(s)

AC098877

Consensus CDS

CCDS27129.1

UniProtKB/Swiss-Prot

O88855

UniProtKB/TrEMBL

A7VJD3

Related

ENSMUSP00000051368.4, ENSMUST00000057569.4

Conserved Domains (1) summary

pfam00001
Location:37 → 285

7tm_1; 7 transmembrane receptor (rhodopsin family)