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Phox2b paired-like homeobox 2b [ Mus musculus (house mouse) ]

Gene ID: 18935, updated on 9-May-2015
Official Symbol
Phox2bprovided by MGI
Official Full Name
paired-like homeobox 2bprovided by MGI
Primary source
MGI:MGI:1100882
See related
Ensembl:ENSMUSG00000012520; Vega:OTTMUSG00000037720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dilp1; Pmx2b; NBPhox
Orthologs
See Phox2b in MapViewer
Location:
5 C3.1; 5 35.95 cM
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (67094397..67099126, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (67485636..67490365, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene LIM and calponin homology domains 1 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene predicted gene, 33040 Neighboring gene predicted gene, 33167 Neighboring gene predicted gene, 33293 Neighboring gene predicted gene, 40314

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
autonomic nervous system development ISO
Inferred from Sequence Orthology
more info
 
cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation in hindbrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to BMP stimulus IDA
Inferred from Direct Assay
more info
PubMed 
dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
efferent axon development in a lateral line nerve IMP
Inferred from Mutant Phenotype
more info
PubMed 
enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindbrain tangential cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
neural crest cell migration involved in autonomic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
noradrenergic neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
noradrenergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
parasympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of respiratory gaseous exchange by neurological system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
respiratory system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrotrapezoid nucleus neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
sympathetic ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
sympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
paired mesoderm homeobox protein 2B
Names
paired mesoderm homeobox protein 2B
GENA 269
PHOX2B homeodomain protein
dilated pupils 1
neuroblastoma Phox
paired mesoderm homeobox 2b

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008888.3NP_032914.1  paired mesoderm homeobox protein 2B

    See identical proteins and their annotated locations for NP_032914.1

    Status: VALIDATED

    Source sequence(s)
    BC079610
    Consensus CDS
    CCDS19316.1
    UniProtKB/Swiss-Prot
    O35690
    Related
    ENSMUSP00000012664, OTTMUSP00000054637, ENSMUST00000012664, OTTMUST00000097414
    Conserved Domains (1) summary
    cd00086
    Location:99157
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    67094397..67099126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    64399184..64403936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)