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    Ephx1 epoxide hydrolase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25315, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ephx1provided by RGD
    Official Full Name
    epoxide hydrolase 1provided by RGD
    Primary source
    RGD:2557
    See related
    Ensembl:ENSRNOG00000003515 AllianceGenome:RGD:2557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mEH; MEH8
    Summary
    Enables cis-stilbene-oxide hydrolase activity; enzyme binding activity; and epoxide hydrolase activity. Involved in several processes, including cellular response to glucocorticoid stimulus; diol biosynthetic process; and liver development. Located in intracellular membrane-bounded organelle and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 2589.7), Kidney (RPKM 779.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (95246079..95275852, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (92714315..92744105, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (99271390..99300580, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481606 Neighboring gene left right determination factor 1 Neighboring gene transmembrane protein 63a Neighboring gene uncharacterized LOC120096328 Neighboring gene epoxide hydrolase 1-like Neighboring gene delta(4)-desaturase, sphingolipid 1 like 1 Neighboring gene ribosomal protein L35, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The clinical relevance and prognostic significance of microsomal epoxide hydrolase gene polymorphisms and their susceptibility to acquired aplastic anemia: an Egyptian study. Makhlouf MM, et al. Biomarkers, 2016 Jul. PMID 26999617
    2. Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer. Khrunin AV, et al. Pharmacogenomics, 2014 Feb. PMID 24533712
    3. Genetic variants and multiple myeloma risk: IMMEnSE validation of the best reported associations--an extensive replication of the associations from the candidate gene era. Martino A, et al. Cancer Epidemiol Biomarkers Prev, 2014 Apr. PMID 24521996
    4. High order interactions of xenobiotic metabolizing genes and P53 codon 72 polymorphisms in acute leukemia. Chauhan PS, et al. Environ Mol Mutagen, 2012 Oct. PMID 22930568
    5. Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE). Bonaventure A, et al. Cancer Causes Control, 2012 Feb. PMID 22200898

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings show the critical role of soluble epoxide hydrolase S-nitrosation in cardiac ischemia-reperfusion injury.
      Title: Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia-reperfusion injury.
    2. involvement of PI3K signaling in regulation of ovarian xenobiotic metabolism by mEH.
      Title: Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling.
    3. The elevated expression of soluble epoxide hydrolase in kidney may play a role in high-salt induced hypertension.
      Title: [Renal over expression of soluble epoxide hydrolase in rat with hypertension induced by high-salt].
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cis-stilbene-oxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-stilbene-oxide hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cis-stilbene-oxide hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-stilbene-oxide hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables epoxide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables epoxide hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables epoxide hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables epoxide hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxysterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxysterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxysterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arachidonic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in arachidonic acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in aromatic compound catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular aromatic compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucocorticoid stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to organic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in diol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epoxide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epoxide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epoxide hydrolase 1
    Names
    epoxide hydratase
    epoxide hydrolase 1 (microsomal xenobiotic hydrolase)
    epoxide hydrolase 1, microsomal (xenobiotic)
    liver microsomal xenobiotic epoxide hydrolase
    microsomal epoxide hydrolase
    NP_001029262.1
    NP_036976.2
    XP_038946306.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034090.4 → NP_001029262.1  epoxide hydrolase 1

      See identical proteins and their annotated locations for NP_001029262.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P07687
      UniProtKB/TrEMBL
      A0A8L2R8K5, A6JGI7
      Related
      ENSRNOP00000034917.6, ENSRNOT00000029787.6
      Conserved Domains (2) summary
      pfam00561
      Location:142 → 401
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam06441
      Location:48 → 157
      EHN; Epoxide hydrolase N-terminus

    2. NM_012844.4 → NP_036976.2  epoxide hydrolase 1

      See identical proteins and their annotated locations for NP_036976.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal non-coding exon compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P07687
      UniProtKB/TrEMBL
      A0A8L2R8K5, A6JGI7
      Related
      ENSRNOP00000004780.2, ENSRNOT00000004780.5
      Conserved Domains (2) summary
      pfam00561
      Location:142 → 401
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam06441
      Location:48 → 157
      EHN; Epoxide hydrolase N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      95246079..95275852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090378.2 → XP_038946306.1  epoxide hydrolase 1 isoform X1

      UniProtKB/Swiss-Prot
      P07687
      UniProtKB/TrEMBL
      A0A8L2R8K5, A6JGI7
      Related
      ENSRNOP00000074206.2
      Conserved Domains (2) summary
      pfam00561
      Location:142 → 401
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam06441
      Location:48 → 157
      EHN; Epoxide hydrolase N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07687.1 GenPept UniProtKB/Swiss-Prot:P07687

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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